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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1980-1-24
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pubmed:abstractText |
We have studied the primary in vitro antibody response toward a hapten in cultures of peripheral blood lymphocytes from twenty-two patients suffering from regular rheumatoid arthritis (RA). These patients were not receiving immunosuppressive drugs or corticosteroids and had not taken Aspirin or non-steroidal anti-inflammatory agents for at least 72 hr. The control groups included thirty-two healthy subjects and twenty-seven control patients. The mean anti-TNP response of the RA patients was significantly lower than that of both control groups. No pre-existing anti-TNP or IgG response could be detected. A search for suppressor cells in co-cultures of RA and normal lymphocytes was negative. On the contrary, the extent of allogeneic enhancement in such co-cultures was comparable to that observed when control lymphocytes were co-cultured. RA serum added to normal lymphocytes cultures showed a dramatic inhibitory effect in only two out of nine cases. A follow-up study has strongly suggested that RA lymphocytes could increase their in vitro antibody response upon treatment.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/159147-1079727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/159147-1080834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/159147-13596783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/159147-13957684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/159147-205611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/159147-300308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/159147-304786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/159147-308252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/159147-401513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/159147-4137918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/159147-4413812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/159147-4503682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/159147-4602329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/159147-5355110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/159147-5388146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/159147-5439527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/159147-6034749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/159147-644244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/159147-65432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/159147-784890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/159147-881555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/159147-944196
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
196-204
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:159147-Adult,
pubmed-meshheading:159147-Antibody Formation,
pubmed-meshheading:159147-Antibody-Producing Cells,
pubmed-meshheading:159147-Arthritis, Rheumatoid,
pubmed-meshheading:159147-Cells, Cultured,
pubmed-meshheading:159147-Concanavalin A,
pubmed-meshheading:159147-Humans,
pubmed-meshheading:159147-Lymphocytes,
pubmed-meshheading:159147-Male,
pubmed-meshheading:159147-Middle Aged,
pubmed-meshheading:159147-T-Lymphocytes, Regulatory,
pubmed-meshheading:159147-Trinitrobenzenes
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pubmed:year |
1979
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pubmed:articleTitle |
Depressed primary in vitro antibody response in rheumatoid arthritis.
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pubmed:publicationType |
Journal Article
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