Linked Life Data

15913848

Source:http://linkedlifedata.com/resource/pubmed/id/15913848

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2005-10-5
pubmed:abstractText
The identification of novel therapeutic agents for the management of malignant gliomas represents an area of active research. Here, we show that among the iron and platinum complexes of 2-hydroxybenzaldehyde semi-/thiosemicarbazones the latter inhibits the growth of C6 glioma cells in vitro with an IC50 value of 45 microM. Structural characterization reveals iron complexes to be octahedral having intermediate S = 3/2 spin states while platinum complexes are found to be square planar moieties. Our findings suggest that the platinum compounds of 2-hydroxybenzaldehyde thiosemicarbazone are potential candidates for the treatment of malignant gliomas.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0223-5234
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1052-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Antiproliferative activities of iron and platinum conjugates of salicylaldehyde semi-/thiosemicarbazones against C6 glioma cells.
pubmed:affiliation
Department of Chemistry, University of Pune, Pune 411007, India.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't