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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2006-2-7
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pubmed:abstractText |
Heparin, one of the most potent anticoagulants widely used for the treatment and prevention of deep vein thrombosis (DVT) and pulmonary embolism (PE), is currently available to patients only by parental administration. In this study, we propose a new oral delivery system of heparin by conjugating it with deoxycholic acid which reformulated by adding dimethyl sulfoxide to increase its bioavailability.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1879-2472
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
117
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
419-27
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pubmed:meshHeading |
pubmed-meshheading:15913716-Administration, Oral,
pubmed-meshheading:15913716-Animals,
pubmed-meshheading:15913716-Anticoagulants,
pubmed-meshheading:15913716-Cholagogues and Choleretics,
pubmed-meshheading:15913716-Deoxycholic Acid,
pubmed-meshheading:15913716-Drug Carriers,
pubmed-meshheading:15913716-Drug Combinations,
pubmed-meshheading:15913716-Drug Compounding,
pubmed-meshheading:15913716-Drug Evaluation, Preclinical,
pubmed-meshheading:15913716-Heparin,
pubmed-meshheading:15913716-Intestines,
pubmed-meshheading:15913716-Male,
pubmed-meshheading:15913716-Mice,
pubmed-meshheading:15913716-Mice, Inbred ICR,
pubmed-meshheading:15913716-Water
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pubmed:year |
2006
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pubmed:articleTitle |
Oral delivery of chemical conjugates of heparin and deoxycholic acid in aqueous formulation.
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pubmed:affiliation |
Center for Cell and Macromolecular Therapy, Department of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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