Linked Life Data

15911591

Source:http://linkedlifedata.com/resource/pubmed/id/15911591

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-8-3
pubmed:abstractText
Inbreeding depression is expected to play an important but complicated role in evolution. If we are to understand the evolution of inbreeding depression (i.e., purging), we need quantitative genetic interpretations of its variation. We introduce an experimental design in which sires are mated to multiple dams, some of which are unrelated to the sire but others are genetically related owing to an arbitrary number of prior generations of selfing or sib-mating. In this way we introduce the concept of "inbreeding depression effect variance," a parameter more relevant to selection and the purging of inbreeding depression than previous measures. We develop an approach for interpreting the genetic basis of the variation in inbreeding depression by: (1) predicting the variation in inbreeding depression given arbitrary initial genetic variance and (2) estimating genetic variance components given half-sib covariances estimated by our experimental design. As quantitative predictions of selection depend upon understanding genetic variation, our approach reveals the important difference between how inbreeding depression is measured experimentally and how it is viewed by selection.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15911591-10937257, http://linkedlifedata.com/resource/pubmed/commentcorrection/15911591-12522429, http://linkedlifedata.com/resource/pubmed/commentcorrection/15911591-14239792, http://linkedlifedata.com/resource/pubmed/commentcorrection/15911591-16589958, http://linkedlifedata.com/resource/pubmed/commentcorrection/15911591-4092925, http://linkedlifedata.com/resource/pubmed/commentcorrection/15911591-5135830, http://linkedlifedata.com/resource/pubmed/commentcorrection/15911591-5728745, http://linkedlifedata.com/resource/pubmed/commentcorrection/15911591-6733226, http://linkedlifedata.com/resource/pubmed/commentcorrection/15911591-6857551, http://linkedlifedata.com/resource/pubmed/commentcorrection/15911591-8582625, http://linkedlifedata.com/resource/pubmed/commentcorrection/15911591-9832540
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0016-6731
pubmed:author
pubmed:issnType
Print
pubmed:volume
170
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1373-84
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
A genetic interpretation of the variation in inbreeding depression.
pubmed:affiliation
Department of Biology, Indiana University, Bloomington, Indiana 47405, USA. jmoorad@indiana.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.