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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2005-5-24
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pubmed:abstractText |
A series of 21 novel 2-[(aminocarbonyl)amino]-5-acetylenyl-3-thiophenecarboxamides were synthesized and evaluated for the inhibition of IKK-2. In spite of their often modest activity on the enzyme, six selected analogs showed significant inhibition of the production of inflammatory cytokine IL-8 in IL-1beta stimulated rheumatoid arthritis-derived synovial fibroblasts, demonstrating their potential usefulness as NF-kappaB regulators.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BonafouxDominiqueD,
pubmed-author:BonarSheriS,
pubmed-author:ChristineLoriL,
pubmed-author:ClareMichaelM,
pubmed-author:DonnellyAnnA,
pubmed-author:GuzovaJuliaJ,
pubmed-author:KenY HYH,
pubmed-author:KishoreNandiniN,
pubmed-author:LennonPatrickP,
pubmed-author:LibbyAdamA,
pubmed-author:MathialaganSumathyS,
pubmed-author:McGheeWilliamW,
pubmed-author:RouwSharonS,
pubmed-author:SommersCindyC,
pubmed-author:TollefsonMichaelM,
pubmed-author:TrippCatherineC,
pubmed-author:WeierRichardR,
pubmed-author:WolfsonSergeS
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2870-5
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
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pubmed:year |
2005
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pubmed:articleTitle |
Inhibition of IKK-2 by 2-[(aminocarbonyl)amino]-5-acetylenyl-3-thiophenecarboxamides.
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pubmed:affiliation |
Department of Medicinal Chemistry, Pfizer Inc., St Louis, MO 63017, USA. bonafoux@biogenidec.com
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pubmed:publicationType |
Journal Article
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