Linked Life Data

15910955

Source:http://linkedlifedata.com/resource/pubmed/id/15910955

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9473
pubmed:dateCreated
2005-5-24
pubmed:abstractText
Adipose tissue expresses cytokines that inhibit insulin signalling pathways in liver and muscle. Obesity also results in impairment of endothelium-dependent vasodilatation in response to insulin. We propose a vasoregulatory role for local deposits of fat around the origin of arterioles supplying skeletal muscle. Isolated first-order arterioles from rat cremaster muscle are under dual regulation by insulin, which activates both endothelin-1 mediated vasoconstriction and nitric-oxide-mediated vasodilatation. In obese rat arterioles, insulin-stimulated NO synthesis is impaired, resulting in unopposed vasoconstriction. We propose that this vasoconstriction is the consequence of production of the adipocytokine tumour necrosis factor alpha from the cuff of fat seen surrounding the origin of the arteriole in obese rats--a depot to which we ascribe a specialist vasoregulatory role. We suggest that this cytokine accesses the nutritive vascular tree to inhibit insulin-mediated capillary recruitment--a mechanism we term "vasocrine" signalling. We also suggest a homology between this vasoactive periarteriolar fat and both periarterial and visceral fat, which may explain relations between visceral fat, insulin resistance, and vascular disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1474-547X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
365
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1817-20
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:articleTitle
"Vasocrine" signalling from perivascular fat: a mechanism linking insulin resistance to vascular disease.
pubmed:affiliation
Diabetes and Cardiovascular Disease Academic Unit, Department of Medicine, Royal Free and University College Medical School, The Archway Campus, Holborn Union Building, 2-10 Highgate Hill, London N19 5LW, UK. j.yudkin@ucl.ac.uk
pubmed:publicationType
Journal Article