Linked Life Data

15909930

Source:http://linkedlifedata.com/resource/pubmed/id/15909930

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2005-5-24
pubmed:abstractText
Abstract: In the search for inhibitors of the non-structural protein 3 (NS3)-associated NTPase/helicase activities of the hepatitis C virus (HCV), and of the related West Nile Virus (WNV), and Japanese Encephalitis Virus (JEV), random screening of a broad range of unrelated low-molecular weight compounds revealed that 4,5,6,7-tetrabromo-1H-benzotriazole (TBBT) is a good inhibitor of the helicase activity of HCV and WNV NTPase/helicases (IC50 >> 20 mM and 1.7 mM with a DNA substrate), but a very weak inhibitor of the JEV enzyme (IC50 >> 200 mM). The synthesis of new TBBT derivatives was undertaken and their inhibitory activities against HCV, WNV, and JEV NTPase/helicases and cytotoxicities were examined. The N-alkyl derivatives showed good activity and lower cytotoxicity than TBBT.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0001-6837
pubmed:author
pubmed:issnType
Print
pubmed:volume
61 Suppl
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
26-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Inhibitors of the NTPase/helicases of hepatitis C and related Flaviviridae viruses.
pubmed:affiliation
Laboratory of Antimetabolites, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 5A Pawi?skiego Str., 02-106 Warszawa, Poland. majka@ibb.waw.pl
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't