Linked Life Data

15909612

Source:http://linkedlifedata.com/resource/pubmed/id/15909612

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2005-5-24
pubmed:abstractText
The lung parenchyma is anatomically and mechanically connected to the intraparenchymal airways. Due to forces of interdependence the lung parenchyma represents a mechanical load that opposes bronchial narrowing during airway smooth muscle activation. The mechanical load caused by the parenchyma is a function of the number of the alveolar attachments to the airways, and of the mechanical properties of the parenchyma. The extracellular matrix is a major component of the lung parenchyma responsible of most of its mechanical properties. The excessive airway narrowing observed in the asthmatic population may be the consequence of the altered mechanical properties of the extracellular matrix reducing the mechanical load that opposes airway smooth muscle contraction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1122-0643
pubmed:author
pubmed:issnType
Print
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
222-5
pubmed:dateRevised
2008-6-2
pubmed:meshHeading
pubmed:articleTitle
The mechanics of the lung parenchyma and airway responsiveness to metacholine.
pubmed:affiliation
Divisione di Pneumologia, Fondazione Salvatore Maugeri, Istituto Scientifico di Cassano delle Murge, Bari, Italy. fsalerno@fsm.it
pubmed:publicationType
Journal Article, In Vitro, Review