Source:http://linkedlifedata.com/resource/pubmed/id/15908974
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2005-8-2
|
| pubmed:abstractText |
CD31 gene polymorphisms are implicated in the pathogenesis of graft-versus-host disease (GvHD) following haematopoietic stem cell transplantation (HST). We investigated the influence of CD31 genotype on the incidence of GvHD following HST from an human leukocyte antigen (HLA)-identical sibling donor. Donor and recipient CD31 codons 125, 563 and 670 DNA polymorphisms were determined in 85 cases of HLA identical sibling HST from two transplant centres. A correlation between CD31 genotype and acute GvHD was considered significant if observed in patients from both transplant centres independently. A strong correlation was identified between donor CD31 codon 125 genotype and the incidence of acute GvHD. Acute GvHD grades II-IV occurred in 27 of 46 (59%) recipients with a CD31 codon 125 leucine / valine heterozygous donor compared to nine of 39 (23%) recipients with a CD31 codon 125 homozygous donor (P=0.0019, relative-risk 2.45, 95% confidence interval 1.3-4.5). This correlation was significant in patients from both transplant centres (P=0.015 and P=0.019). We suggest that CD31 genotype may influence the function of donor-derived leukocytes and may be informative when there is a choice of comparable donors.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
|
| pubmed:issn |
0268-3369
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
36
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
151-6
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| pubmed:meshHeading |
pubmed-meshheading:15908974-Acute Disease,
pubmed-meshheading:15908974-Adolescent,
pubmed-meshheading:15908974-Adult,
pubmed-meshheading:15908974-Amino Acid Substitution,
pubmed-meshheading:15908974-Antigens, CD31,
pubmed-meshheading:15908974-Codon,
pubmed-meshheading:15908974-Cohort Studies,
pubmed-meshheading:15908974-Female,
pubmed-meshheading:15908974-Genotype,
pubmed-meshheading:15908974-Graft vs Host Disease,
pubmed-meshheading:15908974-Hematologic Neoplasms,
pubmed-meshheading:15908974-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:15908974-Heterozygote,
pubmed-meshheading:15908974-Histocompatibility Testing,
pubmed-meshheading:15908974-Humans,
pubmed-meshheading:15908974-Male,
pubmed-meshheading:15908974-Middle Aged,
pubmed-meshheading:15908974-Polymorphism, Genetic,
pubmed-meshheading:15908974-Siblings
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
Donor CD31 genotype and its association with acute graft-versus-host disease in HLA identical sibling stem cell transplantation.
|
| pubmed:affiliation |
Tissue Typing Laboratory, Addenbrooke's Cambridge University Teaching Hospital Trust, Cambridge, UK. reyna.goodman@addenbrookes.nhs.uk
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| pubmed:publicationType |
Journal Article,
Multicenter Study
|