Source:http://linkedlifedata.com/resource/pubmed/id/15908467
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2005-8-15
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| pubmed:abstractText |
Fluid percussion brain injury (FPI) impairs pial artery dilation to activators of the ATP-sensitive (K(ATP)) and calcium-activated (K(Ca)) K(+) channels. This study investigated the role of heat shock protein (HSP) in the modulation of K(+) channel-induced pial artery dilation after FPI in newborn pigs equipped with a closed cranial window. Under nonbrain injury conditions, topical coadministration of exogenous HSP-27 (1 mug/ml) blunted dilation to cromakalim, CGRP, and NS-1619 (10(-8) and 10(-6) M; cromakalim and CGRP are K(ATP) agonists and NS-1619 is a K(Ca) agonist). In contrast, coadministration of exogenous HSP-70 (1 mug/ml) potentiated dilation to cromakalim, CGRP, and NS-1619. FPI increased the cerebrospinal fluid (CSF) concentration of HSP-27 from 0.051 +/- 0.012 to 0.113 +/- 0.035 ng/ml but decreased the CSF concentration of HSP-70 from 50.42 +/- 8.96 to 30.9 +/- 9.9 ng/ml at 1 h postinsult. Pretreatment with topical exogenous HSP-70 (1 mug/ml) before FPI fully blocked injury-induced impairment of cromakalim and CGRP dilation and partially blocked injury-induced impairment of dilation to NS-1619. These data indicate that HSP-27 and HSP-70 contribute to modulation of K(+) channel-induced pial artery dilation. These data suggest that HSP-70 is an endogenous protectant of which its actions may be unmasked and/or potentiated with exogenous administration before brain injury.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Benzimidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Calcitonin Gene-Related Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Cromakalim,
http://linkedlifedata.com/resource/pubmed/chemical/HSP70 Heat-Shock Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Heat-Shock Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NS 1619,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents
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| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
0363-6135
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
289
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
H1184-90
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15908467-Animals,
pubmed-meshheading:15908467-Animals, Newborn,
pubmed-meshheading:15908467-Benzimidazoles,
pubmed-meshheading:15908467-Blood Pressure,
pubmed-meshheading:15908467-Brain Injuries,
pubmed-meshheading:15908467-Calcitonin Gene-Related Peptide,
pubmed-meshheading:15908467-Calcium Channels,
pubmed-meshheading:15908467-Cerebrovascular Circulation,
pubmed-meshheading:15908467-Cromakalim,
pubmed-meshheading:15908467-Female,
pubmed-meshheading:15908467-HSP70 Heat-Shock Proteins,
pubmed-meshheading:15908467-Heat-Shock Proteins,
pubmed-meshheading:15908467-Male,
pubmed-meshheading:15908467-Pia Mater,
pubmed-meshheading:15908467-Potassium Channels,
pubmed-meshheading:15908467-Swine,
pubmed-meshheading:15908467-Vasodilation,
pubmed-meshheading:15908467-Vasodilator Agents
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| pubmed:year |
2005
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| pubmed:articleTitle |
Heat shock protein modulation of KATP and KCa channel cerebrovasodilation after brain injury.
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| pubmed:affiliation |
Department of Anesthesia, University of Pennsylvania, 3620 Hamilton Walk, Rm. 305 John Morgan, Philadelphia, PA 19104, USA. armsteaw@uphs.upenn.edu
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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