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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2005-12-21
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pubmed:abstractText |
Estrogen is the most effective treatment for preventing the vasomotor symptoms in women. The ability of estrogen to control tail skin temperature (TST) in rats is used as an animal model for the studies of estrogens on menopausal hot flushes. Today, we know that estrogen can mediate its actions via the interaction with two different estrogen receptors: ERalpha and ERbeta. To elucidate the function of each estrogen receptor subtype control of thermoregulation, we developed an animal model demonstrating estrogen control of TST in mice.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0378-5122
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
210-6
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pubmed:meshHeading |
pubmed-meshheading:15908148-Animals,
pubmed-meshheading:15908148-Body Temperature Regulation,
pubmed-meshheading:15908148-Estradiol,
pubmed-meshheading:15908148-Estrogen Receptor alpha,
pubmed-meshheading:15908148-Estrogen Receptor beta,
pubmed-meshheading:15908148-Estrogens,
pubmed-meshheading:15908148-Female,
pubmed-meshheading:15908148-Hot Flashes,
pubmed-meshheading:15908148-Male,
pubmed-meshheading:15908148-Mice,
pubmed-meshheading:15908148-Mice, Inbred C57BL,
pubmed-meshheading:15908148-Mice, Knockout,
pubmed-meshheading:15908148-Models, Animal,
pubmed-meshheading:15908148-Ovariectomy,
pubmed-meshheading:15908148-Random Allocation,
pubmed-meshheading:15908148-Skin Temperature,
pubmed-meshheading:15908148-Treatment Outcome
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pubmed:year |
2006
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pubmed:articleTitle |
Estrogenic control of thermoregulation in ERalphaKO and ERbetaKO mice.
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pubmed:affiliation |
Department of Molecular Endocrinology and Bone Biology, Merck Research Laboratories, West Point, PA 19486, USA.
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pubmed:publicationType |
Journal Article
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