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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2005-6-17
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pubmed:abstractText |
The new, highly oxygenated angucyclinone gephyromycin was isolated from an extract of a Streptomyces griseus strain. Its unprecedented ether-bridged structure was elucidated by NMR methods and substantiated by single crystal X-ray analysis. The absolute configuration was evidenced by quantum chemical CD calculations. Gephyromycin exhibits glutaminergic activity towards neuronal cells. Furthermore, the known compounds fridamycin E and dehydrorabelomycin were identified.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0031-9422
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pubmed:author |
pubmed-author:BringmannGerhardG,
pubmed-author:BullAlan TAT,
pubmed-author:DieterAnkeA,
pubmed-author:FiedlerHans-PeterHP,
pubmed-author:GulderTobias A MTA,
pubmed-author:HammAndreasA,
pubmed-author:KocherNikoN,
pubmed-author:LangGerhardG,
pubmed-author:MüllerWerner E GWE,
pubmed-author:MaksimenkaKatjaK,
pubmed-author:StachJames E MJE
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pubmed:issnType |
Print
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1366-73
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15907962-Animals,
pubmed-meshheading:15907962-Anthraquinones,
pubmed-meshheading:15907962-Bridged Compounds,
pubmed-meshheading:15907962-Calcium,
pubmed-meshheading:15907962-Cell Survival,
pubmed-meshheading:15907962-Cells, Cultured,
pubmed-meshheading:15907962-Models, Molecular,
pubmed-meshheading:15907962-Molecular Structure,
pubmed-meshheading:15907962-Neurons,
pubmed-meshheading:15907962-Rats,
pubmed-meshheading:15907962-Streptomyces griseus
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pubmed:year |
2005
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pubmed:articleTitle |
Gephyromycin, the first bridged angucyclinone, from Streptomyces griseus strain NTK 14.
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pubmed:affiliation |
Institut für Organische Chemie, Universität Würzburg, Am Hubland, D-97074 Würzburg, Germany. bringman@chemie.uni-wuerzburg.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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