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| pubmed-article:15907845 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:15907845 | pubmed:dateCreated | 2005-6-6 | lld:pubmed |
| pubmed-article:15907845 | pubmed:abstractText | HIV Tat has been known to have multiple regulatory roles including replication of HIV and modulation of cellular kinases. We investigated whether signaling kinase PKR plays a critical role in mediating Tat-induced cytokine dysregulation. We showed Tat induction of IL-10 dysregulation is associated with PKR activation. To examine the mechanism involved, inhibition of PKR activity abrogated the Tat-induced cytokine induction. We next identified that the MAP kinases including ERK-1/2 and p38 are downstream of PKR in these Tat-induced pathways. Thus, PKR may play a critical role in mediating the subversive effects of HIV Tat resulting in IL-10 induction. | lld:pubmed |
| pubmed-article:15907845 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15907845 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15907845 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15907845 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15907845 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:15907845 | pubmed:author | pubmed-author:LiJames C BJC | lld:pubmed |
| pubmed-article:15907845 | pubmed:author | pubmed-author:LeeDavy C WDC | lld:pubmed |
| pubmed-article:15907845 | pubmed:author | pubmed-author:CheungBenny... | lld:pubmed |
| pubmed-article:15907845 | pubmed:author | pubmed-author:LauAllan S... | lld:pubmed |
| pubmed-article:15907845 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15907845 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:15907845 | pubmed:volume | 579 | lld:pubmed |
| pubmed-article:15907845 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15907845 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15907845 | pubmed:pagination | 3055-62 | lld:pubmed |
| pubmed-article:15907845 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:15907845 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15907845 | pubmed:articleTitle | Mechanisms for HIV Tat upregulation of IL-10 and other cytokine expression: kinase signaling and PKR-mediated immune response. | lld:pubmed |
| pubmed-article:15907845 | pubmed:affiliation | Immunology Research Laboratory, Department of Paediatrics and Adolescent Medicine, Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China. | lld:pubmed |
| pubmed-article:15907845 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15907845 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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