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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0019682,
umls-concept:C0019699,
umls-concept:C0031727,
umls-concept:C0037083,
umls-concept:C0041904,
umls-concept:C0079189,
umls-concept:C0085295,
umls-concept:C0185117,
umls-concept:C0301872,
umls-concept:C0441712,
umls-concept:C0961954,
umls-concept:C1100939,
umls-concept:C1710082,
umls-concept:C2911684
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pubmed:issue |
14
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pubmed:dateCreated |
2005-6-6
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pubmed:abstractText |
HIV Tat has been known to have multiple regulatory roles including replication of HIV and modulation of cellular kinases. We investigated whether signaling kinase PKR plays a critical role in mediating Tat-induced cytokine dysregulation. We showed Tat induction of IL-10 dysregulation is associated with PKR activation. To examine the mechanism involved, inhibition of PKR activity abrogated the Tat-induced cytokine induction. We next identified that the MAP kinases including ERK-1/2 and p38 are downstream of PKR in these Tat-induced pathways. Thus, PKR may play a critical role in mediating the subversive effects of HIV Tat resulting in IL-10 induction.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CCAAT-Enhancer-Binding Protein-delta,
http://linkedlifedata.com/resource/pubmed/chemical/CCAAT-Enhancer-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/CEBPD protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Signal-Regulated MAP...,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, tat,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/eIF-2 Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/tat Gene Products, Human...
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
579
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3055-62
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15907845-CCAAT-Enhancer-Binding Protein-delta,
pubmed-meshheading:15907845-CCAAT-Enhancer-Binding Proteins,
pubmed-meshheading:15907845-Cells, Cultured,
pubmed-meshheading:15907845-Cytokines,
pubmed-meshheading:15907845-Dose-Response Relationship, Drug,
pubmed-meshheading:15907845-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:15907845-Gene Products, tat,
pubmed-meshheading:15907845-HIV-1,
pubmed-meshheading:15907845-Humans,
pubmed-meshheading:15907845-Interleukin-10,
pubmed-meshheading:15907845-Leukocytes,
pubmed-meshheading:15907845-MAP Kinase Signaling System,
pubmed-meshheading:15907845-NF-kappa B,
pubmed-meshheading:15907845-Time Factors,
pubmed-meshheading:15907845-Transcription Factors,
pubmed-meshheading:15907845-Up-Regulation,
pubmed-meshheading:15907845-eIF-2 Kinase,
pubmed-meshheading:15907845-p38 Mitogen-Activated Protein Kinases,
pubmed-meshheading:15907845-tat Gene Products, Human Immunodeficiency Virus
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pubmed:year |
2005
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pubmed:articleTitle |
Mechanisms for HIV Tat upregulation of IL-10 and other cytokine expression: kinase signaling and PKR-mediated immune response.
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pubmed:affiliation |
Immunology Research Laboratory, Department of Paediatrics and Adolescent Medicine, Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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