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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-7-29
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pubmed:abstractText |
Insulin resistance (IR) was reported to be associated with chronic heart failure (CHF). Adiponectin, an insulin-sensitizing hormone with anti-inflammatory activity, improves energy metabolism via AMP-activated protein kinase (AMPK). AMPK deficiency is associated with depressed cardiac function under stress conditions. However, it is not clear whether adiponectin plays an important role in CHF. We hypothesize that deficiency of adiponectin might result in deterioration of heart failure.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0008-6363
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
705-13
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:15907819-Adenylate Kinase,
pubmed-meshheading:15907819-Adiponectin,
pubmed-meshheading:15907819-Animals,
pubmed-meshheading:15907819-Blood Glucose,
pubmed-meshheading:15907819-Blotting, Western,
pubmed-meshheading:15907819-Echocardiography,
pubmed-meshheading:15907819-Fasting,
pubmed-meshheading:15907819-Heart Failure,
pubmed-meshheading:15907819-Insulin,
pubmed-meshheading:15907819-Insulin Resistance,
pubmed-meshheading:15907819-Male,
pubmed-meshheading:15907819-Mice,
pubmed-meshheading:15907819-Mice, Knockout,
pubmed-meshheading:15907819-Myocardium
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pubmed:year |
2005
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pubmed:articleTitle |
Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism.
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pubmed:affiliation |
Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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