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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0022889,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0081620,
umls-concept:C0185117,
umls-concept:C0205245,
umls-concept:C1254042,
umls-concept:C1417833,
umls-concept:C1417834,
umls-concept:C1527148,
umls-concept:C2698420,
umls-concept:C2911684
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pubmed:issue |
5
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pubmed:dateCreated |
2005-6-7
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pubmed:abstractText |
COUP-TFs (chicken ovalbumin upstream promoter-transcription factors) are orphan members of the nuclear receptor superfamily of ligand-activated receptors for which their ligands have not been identified. The two mammalian proteins, COUP-TFI and COUP-TFII, share 80% sequence identity and regulate many aspects of mammalian development and differentiation. In this report, we systemically examined the temporal and spatial expression of COUP-TFI and COUP-TFII transcripts and, for the first time, their protein during development and functional maturation of the cochlea. Both COUP-TFI and COUP-TFII were expressed early in the developing otic vesicle. COUP-TFI expression correlated with the differentiation of hair cells and support cells in the organ of Corti, whereas COUP-TFII expression was down-regulated with differentiation of the organ of Corti. Furthermore, we report for the first time, that the generally nuclear COUP-TFI receptor protein was localized in the cytoplasm of maturing hair cells and pillar cells. Collectively, although COUP-TFI and COUP-TFII are homologues, the expression of each orphan receptor has a restricted and dynamic expression during cochlea development particularly during patterning and differentiation of the cochlear structures.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/COUP Transcription Factor I,
http://linkedlifedata.com/resource/pubmed/chemical/COUP Transcription Factor II,
http://linkedlifedata.com/resource/pubmed/chemical/COUP Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nr2f1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Nr2f2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Steroid,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1567-133X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
587-92
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15907456-Animals,
pubmed-meshheading:15907456-COUP Transcription Factor I,
pubmed-meshheading:15907456-COUP Transcription Factor II,
pubmed-meshheading:15907456-COUP Transcription Factors,
pubmed-meshheading:15907456-Cell Differentiation,
pubmed-meshheading:15907456-Cell Nucleus,
pubmed-meshheading:15907456-Cochlea,
pubmed-meshheading:15907456-DNA-Binding Proteins,
pubmed-meshheading:15907456-Ear, Inner,
pubmed-meshheading:15907456-Epithelial Cells,
pubmed-meshheading:15907456-Gene Expression Regulation, Developmental,
pubmed-meshheading:15907456-Genotype,
pubmed-meshheading:15907456-Hair Cells, Auditory,
pubmed-meshheading:15907456-Immunohistochemistry,
pubmed-meshheading:15907456-In Situ Hybridization,
pubmed-meshheading:15907456-Mice,
pubmed-meshheading:15907456-Models, Anatomic,
pubmed-meshheading:15907456-Organ of Corti,
pubmed-meshheading:15907456-Receptors, Steroid,
pubmed-meshheading:15907456-Time Factors,
pubmed-meshheading:15907456-Transcription Factors
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pubmed:year |
2005
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pubmed:articleTitle |
Dynamic expression of COUP-TFI and COUP-TFII during development and functional maturation of the mouse inner ear.
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pubmed:affiliation |
Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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