Linked Life Data

1590687

Source:http://linkedlifedata.com/resource/pubmed/id/1590687

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1992-6-22
pubmed:abstractText
The doubling times of bacteria at sites of colonization or infection are considerably longer than those in laboratory culture media, and slow growth reduces the susceptibility of bacteria to antimicrobial agents. Helicobacter pylori is susceptible to a wide range of antimicrobial agents in vitro; however, tests for inhibitory activity do not adequately predict which antimicrobial agents will eradicate slowly growing H. pylori from the stomachs of patients. The chemostat can be used to compare the bactericidal activities of antimicrobial substances against slowly growing bacteria. In this study we compared the bactericidal activities of antimicrobial agents against slowly growing H. pylori. The bactericidal activities of erythromycin, minocycline, ampicillin, amoxicillin, cefixime, metronidazole, and bismuth subcitrate against slowly growing H. pylori NCTC 11,637 in a chemostat were compared. Antimicrobial agents were added to the system at four to eight times the MIC. Exposure of H. pylori to metronidazole was associated with the rapid development of metronidazole resistance, preventing assessment of the bactericidal activity of metronidazole. Resistance to the other antimicrobial agents tested did not develop. The poor bactericidal activities of the antimicrobial agents against slowly growing H. pylori may be a contributory factor in limiting their clinical efficacies. Of the agents tested, only amoxicillin and bismuth subcitrate showed bactericidal activity against slowly growing H. pylori. The chemostat allows comparison of the bactericidal activities of antimicrobial agents against slowly growing H. pylori and may therefore provide results which more accurately identify those agents or combinations of agents that will eradicate H. pylori from patients.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1590687-1898444, http://linkedlifedata.com/resource/pubmed/commentcorrection/1590687-1971318, http://linkedlifedata.com/resource/pubmed/commentcorrection/1590687-2393285, http://linkedlifedata.com/resource/pubmed/commentcorrection/1590687-2511804, http://linkedlifedata.com/resource/pubmed/commentcorrection/1590687-3089141, http://linkedlifedata.com/resource/pubmed/commentcorrection/1590687-3166527, http://linkedlifedata.com/resource/pubmed/commentcorrection/1590687-3280609, http://linkedlifedata.com/resource/pubmed/commentcorrection/1590687-3694664, http://linkedlifedata.com/resource/pubmed/commentcorrection/1590687-3700291, http://linkedlifedata.com/resource/pubmed/commentcorrection/1590687-4053491, http://linkedlifedata.com/resource/pubmed/commentcorrection/1590687-4586142, http://linkedlifedata.com/resource/pubmed/commentcorrection/1590687-4587820, http://linkedlifedata.com/resource/pubmed/commentcorrection/1590687-4884387, http://linkedlifedata.com/resource/pubmed/commentcorrection/1590687-6175466
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0066-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
185-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Bactericidal activity of antimicrobial agents against slowly growing Helicobacter pylori.
pubmed:affiliation
Department of Microbiology and Pathology, Bristol Royal Infirmary, United Kingdom.
pubmed:publicationType
Journal Article, Comparative Study