Linked Life Data

15906535

Source:http://linkedlifedata.com/resource/pubmed/id/15906535

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2005-5-23
pubmed:abstractText
We investigated the localization of type XV collagen in normal human skin and skin tumors by immunohistochemical methods using a monoclonal antibody against the recombinant polypeptide of the non-collagenous region of the alpha1 chain of murine type XV collagen. Type XV collagen was localized in the dermo-epidermal, perivascular, and perineural basement membrane zones in normal skin. While this localization appeared to be similar to that of type IV collagen, detailed observation revealed that its localization was distinct in fact from that of type IV collagen which was thin and linear in appearance and was distributed inside organs. Type XV collagen was distributed broadly and zonally outside organs such as vascular and neural tissues. It was expressed at low levels in seborrheic keratosis and not expressed at all in actinic keratosis and squamous cell carcinoma. Melanocytic nevi and malignant melanomas in situ were positive for type XV collagen; melanomas with dermal invasion were negative. These findings suggest that type XV collagen plays a role in the adherence of the basement membrane to surrounding connective tissue and that it may be associated with the tumorigenesis of keratinocytes and melanocytes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0385-2407
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
74-83
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Immunohistochemical studies comparing the localization of type XV collagen in normal human skin and skin tumors with that of type IV collagen.
pubmed:affiliation
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, Japan.
pubmed:publicationType
Journal Article