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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2005-9-13
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pubmed:abstractText |
In Jurkat cells, the decreased cell growth rate associated with a long-lasting deactivation of the mammalian target of rapamycin (mTOR)/p70 ribosomal S6 kinase (S6K)-signaling pathway generates a cell population of progressively reduced cellular mass and size. When promoted by rapamycin as prototype inhibitor, the mTOR deactivation-dependent cell size reduction was associated with slowed, but not suppressed, proliferation. Small-size cells were significantly protected from apoptosis induced by Fas/Apo-1 death-receptor activation (as shown by reduced procaspase cleavage and decreased catalytic activity of relevant caspases) or by stress signals-dependent mitochondrial perturbation (as shown by reduced cleavage of caspase-2, lower dissipation of mitochondrial membrane potential and decreased release of cytochorome c and apoptosis-inducing factor from mitochondria). Protection faded when reactivation of the mTOR/S6K pathway promoted the cell recovery to normal size. These results suggest that cells induced to reduce their mass by the mTOR deactivation-dependent inhibition of cell growth become more resilient to lethal assaults by curbing the cell's suicidal response.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-(4-morpholinyl)-8-phenyl-4H-1-benz...,
http://linkedlifedata.com/resource/pubmed/chemical/Chromones,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome c Group,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Leucine,
http://linkedlifedata.com/resource/pubmed/chemical/MTOR protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Mitochondrial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Morpholines,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Ribosomal Protein S6 Kinases, 70-kDa,
http://linkedlifedata.com/resource/pubmed/chemical/Sirolimus,
http://linkedlifedata.com/resource/pubmed/chemical/TOR Serine-Threonine Kinases
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1350-9047
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1344-57
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15905878-Apoptosis,
pubmed-meshheading:15905878-Cell Growth Processes,
pubmed-meshheading:15905878-Cell Size,
pubmed-meshheading:15905878-Chromones,
pubmed-meshheading:15905878-Cytochrome c Group,
pubmed-meshheading:15905878-Energy Metabolism,
pubmed-meshheading:15905878-Enzyme Inhibitors,
pubmed-meshheading:15905878-Humans,
pubmed-meshheading:15905878-Jurkat Cells,
pubmed-meshheading:15905878-Leucine,
pubmed-meshheading:15905878-Mitochondria,
pubmed-meshheading:15905878-Mitochondrial Proteins,
pubmed-meshheading:15905878-Morpholines,
pubmed-meshheading:15905878-Phosphorylation,
pubmed-meshheading:15905878-Protein Kinases,
pubmed-meshheading:15905878-Ribosomal Protein S6 Kinases, 70-kDa,
pubmed-meshheading:15905878-Sirolimus,
pubmed-meshheading:15905878-TOR Serine-Threonine Kinases
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pubmed:year |
2005
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pubmed:articleTitle |
Cell size reduction induced by inhibition of the mTOR/S6K-signaling pathway protects Jurkat cells from apoptosis.
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pubmed:affiliation |
Department of Experimental Medicine, Division of Molecular Pathology and Immunology. University of Parma, Parma 43100, Italy. claudia.fumarola@unipr.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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