|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
11
|
|
pubmed:dateCreated |
2005-5-20
|
|
pubmed:abstractText |
OVA-induced allergic diarrhea occurs as a consequence of over-expression of Th1 inhibitory IL-12p40 monomers and homodimers in the large intestine, establishing a dominant Th2-type environment. In this study, we demonstrate that intranasally administered murine IL-12p70 naked DNA expression plasmids resulted in the synthesis of corresponding cytokine in the large intestinal CD11c(+) dendritic cells, leading to the inhibition of Ag-specific Th2-type response for the prevention of allergic diarrhea and the suppression of clinical symptoms including OVA-specific IgE Ab synthesis. The nasal IL-12p70 DNA treatment proved effective even after the establishment of allergic diarrhea. These results suggest that the mucosal administration of naked IL-12p70 DNA plasmid should be considered as a possible preventive and therapeutic treatment for Th2 cell-mediated food allergic diseases in the intestinal tract.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0022-1767
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
174
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
7423-32
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:15905591-Administration, Intranasal,
pubmed-meshheading:15905591-Colitis,
pubmed-meshheading:15905591-Cytokines,
pubmed-meshheading:15905591-Diarrhea,
pubmed-meshheading:15905591-Down-Regulation,
pubmed-meshheading:15905591-Gene Therapy,
pubmed-meshheading:15905591-Green Fluorescent Proteins,
pubmed-meshheading:15905591-Immunoglobulin A,
pubmed-meshheading:15905591-Immunoglobulin G,
pubmed-meshheading:15905591-Interleukin-12,
pubmed-meshheading:15905591-Intestine, Large,
pubmed-meshheading:15905591-Lymphoid Tissue,
pubmed-meshheading:15905591-Nasopharynx,
pubmed-meshheading:15905591-Ovalbumin,
pubmed-meshheading:15905591-Plasmids,
pubmed-meshheading:15905591-Protein Subunits,
pubmed-meshheading:15905591-Spleen,
pubmed-meshheading:15905591-Th2 Cells,
pubmed-meshheading:15905591-Vaccines, DNA
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Nasal IL-12p70 DNA prevents and treats intestinal allergic diarrhea.
|
|
pubmed:affiliation |
Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Japan.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
