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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2005-5-20
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pubmed:abstractText |
A numerical and functional deficiency in invariant NKT (iNKT) cells detectable by 3 wk of age in the thymus and spleen mediates the pathogenesis of type 1 diabetes in NOD mice, but the stage of T cell development at which this deficiency first occurs is unknown. We report in this study that this deficiency develops after the CD4(+)CD8(+) double-positive stage of thymic T cell development and is due to a lineage-specific depletion of CD4(-)CD8(-) double-negative alphabeta T cells and iNKT cells from the thymus between embryonic day 18 and day 1 after birth. Thus, an inheritable defect in a lineage fate decision that elicits a deficiency in fetal thymic iNKT cell development may predispose to susceptibility to type 1 diabetes.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
174
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6764-71
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:15905517-Animals,
pubmed-meshheading:15905517-Animals, Newborn,
pubmed-meshheading:15905517-Cell Differentiation,
pubmed-meshheading:15905517-Cell Lineage,
pubmed-meshheading:15905517-Diabetes Mellitus, Type 1,
pubmed-meshheading:15905517-Female,
pubmed-meshheading:15905517-Fetus,
pubmed-meshheading:15905517-Genetic Predisposition to Disease,
pubmed-meshheading:15905517-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:15905517-Killer Cells, Natural,
pubmed-meshheading:15905517-Lymphopenia,
pubmed-meshheading:15905517-Membrane Proteins,
pubmed-meshheading:15905517-Mice,
pubmed-meshheading:15905517-Mice, Inbred C57BL,
pubmed-meshheading:15905517-Mice, Inbred NOD,
pubmed-meshheading:15905517-Organ Culture Techniques,
pubmed-meshheading:15905517-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:15905517-T-Lymphocyte Subsets,
pubmed-meshheading:15905517-Thymus Gland
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pubmed:year |
2005
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pubmed:articleTitle |
A defect in lineage fate decision during fetal thymic invariant NKT cell development may regulate susceptibility to type 1 diabetes.
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pubmed:affiliation |
Autoimmunity/Diabetes, Robarts Research Institute, University of Western Ontario, London, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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