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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5725
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pubmed:dateCreated |
2005-5-20
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pubmed:abstractText |
beta-Catenin is a multifunctional protein that mediates Wnt signaling by binding to members of the T cell factor (TCF) family of transcription factors. Here, we report an evolutionarily conserved interaction of beta-catenin with FOXO transcription factors, which are regulated by insulin and oxidative stress signaling. beta-Catenin binds directly to FOXO and enhances FOXO transcriptional activity in mammalian cells. In Caenorhabditis elegans, loss of the beta-catenin BAR-1 reduces the activity of the FOXO ortholog DAF-16 in dauer formation and life span. Association of beta-catenin with FOXO was enhanced in cells exposed to oxidative stress. Furthermore, BAR-1 was required for the oxidative stress-induced expression of the DAF-16 target gene sod-3 and for resistance to oxidative damage. These results demonstrate a role for beta-catenin in regulating FOXO function that is particularly important under conditions of oxidative stress.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CDKN1B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CTNNB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Catnb protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DAF-2 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/FOXO1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/FOXO4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrogen Peroxide,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Lithium Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxide Dismutase,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/bar-1 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin,
http://linkedlifedata.com/resource/pubmed/chemical/daf-16 protein, C elegans
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
20
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pubmed:volume |
308
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1181-4
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:15905404-Animals,
pubmed-meshheading:15905404-Animals, Genetically Modified,
pubmed-meshheading:15905404-Caenorhabditis elegans,
pubmed-meshheading:15905404-Caenorhabditis elegans Proteins,
pubmed-meshheading:15905404-Carrier Proteins,
pubmed-meshheading:15905404-Cell Cycle,
pubmed-meshheading:15905404-Cell Line,
pubmed-meshheading:15905404-Cell Line, Tumor,
pubmed-meshheading:15905404-Cyclin-Dependent Kinase Inhibitor p27,
pubmed-meshheading:15905404-Cytoskeletal Proteins,
pubmed-meshheading:15905404-DNA-Binding Proteins,
pubmed-meshheading:15905404-Forkhead Transcription Factors,
pubmed-meshheading:15905404-Humans,
pubmed-meshheading:15905404-Hydrogen Peroxide,
pubmed-meshheading:15905404-Immunoprecipitation,
pubmed-meshheading:15905404-Insulin,
pubmed-meshheading:15905404-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:15905404-Lithium Chloride,
pubmed-meshheading:15905404-Longevity,
pubmed-meshheading:15905404-Mice,
pubmed-meshheading:15905404-Mutation,
pubmed-meshheading:15905404-Oxidative Stress,
pubmed-meshheading:15905404-Receptor, Insulin,
pubmed-meshheading:15905404-Signal Transduction,
pubmed-meshheading:15905404-Superoxide Dismutase,
pubmed-meshheading:15905404-Trans-Activators,
pubmed-meshheading:15905404-Transcription Factors,
pubmed-meshheading:15905404-Transfection,
pubmed-meshheading:15905404-beta Catenin
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pubmed:year |
2005
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pubmed:articleTitle |
Functional interaction between beta-catenin and FOXO in oxidative stress signaling.
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pubmed:affiliation |
Department of Physiological Chemistry and Center for Biomedical Genetics, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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