Source:http://linkedlifedata.com/resource/pubmed/id/15904995
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2006-4-18
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| pubmed:abstractText |
Frontotemporal dementia (FTD) is a complex dementing syndrome whose genetic/non genetic risk factors are mostly unknown. Aim of the present work was to investigate whether APOE and/or tau gene variability does affect the risk of FTD. A sample of FTD cases (sporadic: n = 54; familial: n = 46, one subject per family) was collected in a genetically homogeneous population (Calabria, southern Italy) and analyzed in comparison with an age- and sex-matched control group (n = 180) extracted from the same population. Logistic regression analysis showed that APOE gene variability affects the probability of disease, with allele epsilon4 increasing (exp(beta1) = 2.68 with [1.51-4.76] 95% confidence interval; p = 0.001) and allele epsilon2 decreasing (exp(beta1) = 0.28 with [0.12-0.66] 95% confidence interval; p = 0.003) the risk of FTD. On the contrary, tau gene variability was ineffectual (exp(beta1) non significantly different from 1 for either H1 or H2 haplotypes), although a small effect was observed by the H1 haplotype in increasing the protective effect of the epsilon2 allele (p = 0.007).
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
1558-1497
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| pubmed:author |
pubmed-author:BernardiLL,
pubmed-author:BruniA CAC,
pubmed-author:ColasNN,
pubmed-author:CurcioS A MSA,
pubmed-author:De BenedictisGG,
pubmed-author:Di NataleMM,
pubmed-author:KawaraiTT,
pubmed-author:LongoTT,
pubmed-author:MalettaR GRG,
pubmed-author:MirabelliMM,
pubmed-author:PassarinoGG,
pubmed-author:PerriMM,
pubmed-author:PuccioGG,
pubmed-author:RogaevaEE,
pubmed-author:SmirneNN,
pubmed-author:St George HyslopP HPH,
pubmed-author:TomainoCC
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
27
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
702-9
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:15904995-Adult,
pubmed-meshheading:15904995-Aged,
pubmed-meshheading:15904995-Aged, 80 and over,
pubmed-meshheading:15904995-Apolipoproteins E,
pubmed-meshheading:15904995-Brain,
pubmed-meshheading:15904995-DNA,
pubmed-meshheading:15904995-DNA Mutational Analysis,
pubmed-meshheading:15904995-Dementia,
pubmed-meshheading:15904995-Female,
pubmed-meshheading:15904995-Genetic Variation,
pubmed-meshheading:15904995-Haplotypes,
pubmed-meshheading:15904995-Humans,
pubmed-meshheading:15904995-Logistic Models,
pubmed-meshheading:15904995-Male,
pubmed-meshheading:15904995-Middle Aged,
pubmed-meshheading:15904995-Neuropsychological Tests,
pubmed-meshheading:15904995-Risk,
pubmed-meshheading:15904995-tau Proteins
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
The effects of APOE and tau gene variability on risk of frontotemporal dementia.
|
| pubmed:affiliation |
Regional Neurogenetic Centre, ASL 6 Viale A. Perugini, 88046 Lamezia Terme, CZ, Italy.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|