Linked Life Data

15902285

Source:http://linkedlifedata.com/resource/pubmed/id/15902285

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2005-7-21
pubmed:abstractText
The role of TP53 mutation in transformation of follicular lymphoma (FL) to diffuse large B-cell lymphoma (t-FL) was examined in a panel of 91 lymph node biopsies derived from 29 patients pre- and post-transformation. The entire TP53 coding sequence was screened and immunocytochemistry performed to determine expression of p53 and its key regulator MDM2. A total of 10 mutations were detected in eight patients (28%), although none were present at FL diagnosis. Mutations were not detected solely at the time of transformation; in three patients, mutated TP53 arose in at least one antecedent FL sample (6 months, 2.5 years and 4 years prior to transformation). Loss of heterozygosity at the TP53 locus occurred in 2/20 informative patients (only in t-FL samples). p53 staining was positive in 82% (9/11) of available biopsies with a missense mutation, and negative in 71% (45/63) with wtTP53. MDM2 expression was significantly higher in t-FL samples (mean 72% positive; 95% confidence interval (95% CI) 68-76%) than FL (mean 58% positive; 95% CI 54-62%) (P<0.001) but did not correlate with TP53 status. TP53 mutation has only a limited role in the transformation of FL, exerting a heterogeneous influence upon phenotypic change. In contrast, dysregulation of MDM2 is frequent and may provide a more rational therapeutic target..
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0887-6924
pubmed:author
pubmed:copyrightInfo
Leukemia (2005) 19, 1459-1465.
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1459-65
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:15902285-Cell Transformation, Neoplastic, pubmed-meshheading:15902285-Gene Expression Regulation, Neoplastic, pubmed-meshheading:15902285-Humans, pubmed-meshheading:15902285-Immunohistochemistry, pubmed-meshheading:15902285-Loss of Heterozygosity, pubmed-meshheading:15902285-Lymph Nodes, pubmed-meshheading:15902285-Lymphoma, B-Cell, pubmed-meshheading:15902285-Lymphoma, Follicular, pubmed-meshheading:15902285-Lymphoma, Large B-Cell, Diffuse, pubmed-meshheading:15902285-Mutation, pubmed-meshheading:15902285-Mutation, Missense, pubmed-meshheading:15902285-Neoplasm Proteins, pubmed-meshheading:15902285-Nuclear Proteins, pubmed-meshheading:15902285-Proto-Oncogene Proteins, pubmed-meshheading:15902285-Proto-Oncogene Proteins c-mdm2, pubmed-meshheading:15902285-Tumor Suppressor Protein p53
pubmed:year
2005
pubmed:articleTitle
A limited role for TP53 mutation in the transformation of follicular lymphoma to diffuse large B-cell lymphoma.
pubmed:affiliation
Cancer Research UK Medical Oncology Unit, Bart's and The Royal London School of Medicine and Dentistry, London, UK. Andrew.J.Davies@cancer.org.uk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't