| pubmed-article:15902271 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15902271 | lifeskim:mentions | umls-concept:C1155065 | lld:lifeskim |
| pubmed-article:15902271 | lifeskim:mentions | umls-concept:C0081889 | lld:lifeskim |
| pubmed-article:15902271 | lifeskim:mentions | umls-concept:C1858663 | lld:lifeskim |
| pubmed-article:15902271 | lifeskim:mentions | umls-concept:C0887840 | lld:lifeskim |
| pubmed-article:15902271 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:15902271 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:15902271 | pubmed:dateCreated | 2005-6-15 | lld:pubmed |
| pubmed-article:15902271 | pubmed:abstractText | Calcium signaling is critical for activation of T lymphocytes and has been proposed to be transduced through multiple calmodulin target proteins. Whereas the calcineurin-NFAT signaling module is critical for all mammalian T cells, the role of calmodulin-dependent kinase IV (CaMKIV) in mouse naïve CD4+ T-cell activation remains enigmatic. We have applied lentivius-mediated RNA interference of CaMKIV to human T cells and found that knockdown of CaMKIV abrogates T-cell receptor-mediated transcription of the IL-2 gene. We demonstrate that CaMKIV directly phosphorylates Cabin1, a transcriptional corepressor for myocyte enhancer factor 2, creating a docking site for 14-3-3, which causes its nuclear export. CaMKIV-mediated nuclear export of Cabin1 is likely to account for a significant part of the requirement of CaMKIV during human T-cell activation. | lld:pubmed |
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| pubmed-article:15902271 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15902271 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15902271 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15902271 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15902271 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:15902271 | pubmed:author | pubmed-author:DewL LLL | lld:pubmed |
| pubmed-article:15902271 | pubmed:author | pubmed-author:MeansAnthony... | lld:pubmed |
| pubmed-article:15902271 | pubmed:author | pubmed-author:LiuJun OJO | lld:pubmed |
| pubmed-article:15902271 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15902271 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:15902271 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:15902271 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15902271 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15902271 | pubmed:pagination | 2104-13 | lld:pubmed |
| pubmed-article:15902271 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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