Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2005-6-15
pubmed:abstractText
Calcium signaling is critical for activation of T lymphocytes and has been proposed to be transduced through multiple calmodulin target proteins. Whereas the calcineurin-NFAT signaling module is critical for all mammalian T cells, the role of calmodulin-dependent kinase IV (CaMKIV) in mouse naïve CD4+ T-cell activation remains enigmatic. We have applied lentivius-mediated RNA interference of CaMKIV to human T cells and found that knockdown of CaMKIV abrogates T-cell receptor-mediated transcription of the IL-2 gene. We demonstrate that CaMKIV directly phosphorylates Cabin1, a transcriptional corepressor for myocyte enhancer factor 2, creating a docking site for 14-3-3, which causes its nuclear export. CaMKIV-mediated nuclear export of Cabin1 is likely to account for a significant part of the requirement of CaMKIV during human T-cell activation.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-10487760, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-10487761, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-10488331, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-10531067, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-10617605, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-10869435, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-10933397, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-10958686, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-10964952, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-11046135, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-11114892, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-11244045, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-11264466, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-11470791, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-11714752, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-11739719, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-11796223, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-12518064, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-12552109, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-12626519, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-14722108, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-15166223, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-15367659, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-1646483, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-3091377, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-3871211, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-3918270, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-7691065, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-7979236, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-8065343, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-8195196, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-8702940, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-8816492, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-9143705, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-9171236, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-9452427, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-9655484, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-9660798, http://linkedlifedata.com/resource/pubmed/commentcorrection/15902271-9753748
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/14-3-3 Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing, http://linkedlifedata.com/resource/pubmed/chemical/CABIN1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/CAMK4 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Calcineurin, http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent..., http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent..., http://linkedlifedata.com/resource/pubmed/chemical/Calmodulin, http://linkedlifedata.com/resource/pubmed/chemical/Camk4 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2, http://linkedlifedata.com/resource/pubmed/chemical/Ionomycin, http://linkedlifedata.com/resource/pubmed/chemical/Ionophores, http://linkedlifedata.com/resource/pubmed/chemical/Myogenic Regulatory Factors, http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/myocyte-specific enhancer-binding...
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0261-4189
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2104-13
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
More...