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rdf:type |
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lifeskim:mentions |
umls-concept:C0002072,
umls-concept:C0063083,
umls-concept:C0205245,
umls-concept:C0205314,
umls-concept:C0380603,
umls-concept:C0441513,
umls-concept:C0441655,
umls-concept:C0597998,
umls-concept:C0679622,
umls-concept:C1527177,
umls-concept:C1723263
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pubmed:issue |
4
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pubmed:dateCreated |
2005-5-30
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pubmed:abstractText |
Poly(gamma-glutamic acid)-sulfonate (gamma-PGA-S) hydrogel, with fibroblast growth factor (FGF)-2 activity was investigated as a novel, next-generation tissue-engineering material. gamma-PGA-net-gamma-PGA-S72 (S72-netgel) was prepared with gamma-PGA-S and gamma-PGA-S72 (72% sulfonated gamma-PGA) to provide the high mobility of gamma-PGA-S72 for FGF-2 activity. Cell adhesion and proliferation activities were evaluated on gamma-PGA and gamma-PGA-S hydrogels along with S72-netgels. Both cell adhesion and proliferation activities of gamma-PGA and gamma-PGA-S hydrogels were low. In contrast, S72-netgels had high cell adhesion and proliferation activities, because of their low swelling ratios and high sulfonic acid group concentrations. Furthermore, S72-netgels had high FGF-2 activity, because gamma-PGA-S72 retained FGF-2 activity when incorporated into S72-netgels. S72-netgels should be useful as next-generation tissue-engineering material containing FGF-2 activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1549-3296
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pubmed:author |
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pubmed:copyrightInfo |
(c) 2005 Wiley Periodicals, Inc.
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
485-91
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15900608-Animals,
pubmed-meshheading:15900608-Biocompatible Materials,
pubmed-meshheading:15900608-Biodegradation, Environmental,
pubmed-meshheading:15900608-Cell Adhesion,
pubmed-meshheading:15900608-Cell Line,
pubmed-meshheading:15900608-Cell Proliferation,
pubmed-meshheading:15900608-Fibroblast Growth Factor 2,
pubmed-meshheading:15900608-Fibroblasts,
pubmed-meshheading:15900608-Hydrogel,
pubmed-meshheading:15900608-Hydrogels,
pubmed-meshheading:15900608-Mice,
pubmed-meshheading:15900608-Models, Chemical,
pubmed-meshheading:15900608-Polyglutamic Acid,
pubmed-meshheading:15900608-Polymers,
pubmed-meshheading:15900608-Sulfonic Acids,
pubmed-meshheading:15900608-Temperature,
pubmed-meshheading:15900608-Time Factors,
pubmed-meshheading:15900608-Tissue Engineering
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pubmed:year |
2005
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pubmed:articleTitle |
Novel functional biodegradable polymer. III. The construction of poly(gamma-glutamic acid)-sulfonate hydrogel with fibroblast growth factor-2 activity.
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pubmed:affiliation |
Department of Nanostructured and Advanced Materials, Graduate School of Science and Engineering, Kagoshima University, 1-21-40 Korimoto, Kagoshima 890-0065, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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