15899556

Source:http://linkedlifedata.com/resource/pubmed/id/15899556

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0006870, umls-concept:C0013216, umls-concept:C0035647, umls-concept:C0282443, umls-concept:C0683525, umls-concept:C1552617
pubmed:issue	2
pubmed:dateCreated	2005-10-11
pubmed:abstractText	Despite the fact that rates of cannabis dependence have increased substantially over the past several years, there are no medications approved for the treatment of cannabis dependence. This paper reviews data from recent research on cannabinoids that may be relevant for the development of pharmacotherapies for cannabis dependence. Included in the discussion are findings from studies that have assessed the ability of medications to ameliorate cannabis-related abstinence symptoms in laboratory animals and human research participants. Data from studies that have investigated the effects of pharmacological agents on cannabis self-administration are also reviewed because these data may provide information critical for informing relapse prevention medication development efforts. The majority of published studies evaluating cannabis pharmacotherapies have focused on decreasing withdrawal symptoms: a growing number of medications reduce symptoms in laboratory animals, but the majority of these medications have not been tested in humans. Fewer studies have assessed the effects of potential cannabis treatment medications on cannabinoid-related reinforcing effects. In laboratory animals, only the CB1 cannabinoid antagonist rimonabant has shown promise. In humans, this medication has not been tested on cannabis reinforcing effects. To date, no medication has been shown to alter cannabis self-administration by humans.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/DA-03746
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7513587
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Nov
pubmed:issn	0376-8716
pubmed:author	pubmed-author:HartCarl LCL
pubmed:issnType	Print
pubmed:day	1
pubmed:volume	80
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	147-59
pubmed:dateRevised	2007-11-14
pubmed:meshHeading	pubmed-meshheading:15899556-Drug Therapy, pubmed-meshheading:15899556-Humans, pubmed-meshheading:15899556-Marijuana Abuse, pubmed-meshheading:15899556-Recurrence
pubmed:year	2005
pubmed:articleTitle	Increasing treatment options for cannabis dependence: a review of potential pharmacotherapies.
pubmed:affiliation	Division on Substance Abuse, New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons, Columbia University, 1051 Riverside Dr., Unit 120, New York, NY 10032, USA. clh42@columbia.edu
pubmed:publicationType	Journal Article, Review, Research Support, N.I.H., Extramural