| pubmed-article:15897679 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15897679 | lifeskim:mentions | umls-concept:C1123023 | lld:lifeskim |
| pubmed-article:15897679 | lifeskim:mentions | umls-concept:C0024880 | lld:lifeskim |
| pubmed-article:15897679 | lifeskim:mentions | umls-concept:C0019595 | lld:lifeskim |
| pubmed-article:15897679 | lifeskim:mentions | umls-concept:C0486805 | lld:lifeskim |
| pubmed-article:15897679 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15897679 | lifeskim:mentions | umls-concept:C0066772 | lld:lifeskim |
| pubmed-article:15897679 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15897679 | pubmed:dateCreated | 2005-10-24 | lld:pubmed |
| pubmed-article:15897679 | pubmed:abstractText | The present study examined whether lysophosphatidic acid (LPA) induces histamine release and the role of Rho-associated protein kinase (ROCK) in histamine release utilizing Y-27632, an inhibitor of ROCK. Rat peritoneal mast cells and mouse skin fragments were challenged with LPA; subsequently, histamine contents were measured by spectrofluorometric assay. LPA-induced histamine release from mast cells and skin fragments occurred in a time- and dose-dependent manner Pretreatment with Y-27632 inhibited LPA-induced histamine release in a dose-dependent fashion. LPA-induced histamine release was not influenced by calcium-free conditions; however, A23187-induced histamine release decreased significantly. TMB-8, an intracellular calcium antagonist, dose-dependently inhibited the histamine release under these conditions. Additionally, Y-27632 scarcely affected A23187-induced histamine release. These findings suggest that LPA-induced histamine release may be attributable to calcium release from intracellular stores. Moreover, ROCK participates in the extracellular calcium-independent process of LPA-induced histamine release. | lld:pubmed |
| pubmed-article:15897679 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15897679 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15897679 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15897679 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15897679 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15897679 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15897679 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15897679 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15897679 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15897679 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15897679 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15897679 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15897679 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15897679 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15897679 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15897679 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15897679 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15897679 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15897679 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15897679 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:15897679 | pubmed:issn | 0031-7012 | lld:pubmed |
| pubmed-article:15897679 | pubmed:author | pubmed-author:HashimotoTeru... | lld:pubmed |
| pubmed-article:15897679 | pubmed:author | pubmed-author:OhataHisayuki... | lld:pubmed |
| pubmed-article:15897679 | pubmed:author | pubmed-author:MomoseKazutak... | lld:pubmed |
| pubmed-article:15897679 | pubmed:author | pubmed-author:HondaKazuoK | lld:pubmed |
| pubmed-article:15897679 | pubmed:copyrightInfo | Copyright (c) 2005 S. Karger AG, Basel. | lld:pubmed |
| pubmed-article:15897679 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15897679 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:15897679 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15897679 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15897679 | pubmed:pagination | 13-20 | lld:pubmed |
| pubmed-article:15897679 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:15897679 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15897679 | pubmed:articleTitle | Lysophosphatidic acid induces histamine release from mast cells and skin fragments. | lld:pubmed |
| pubmed-article:15897679 | pubmed:affiliation | Department of Pharmacology, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan. | lld:pubmed |
| pubmed-article:15897679 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15897679 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15897679 | pubmed:publicationType | In Vitro | lld:pubmed |
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