Source:http://linkedlifedata.com/resource/pubmed/id/15896841
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
2005-9-16
|
| pubmed:abstractText |
We have developed a novel murine model for B-CLL by engrafting human prolymphocytic leukemia (PLL) or B-CLL cell line cells (JVM-3 and MEC-2 cell lines, respectively) into nude mice. Not only treatment of the mice was a prerequisite for the success of the graft, but also for the first time, females appeared to accept the cells more easily than males. Surprisingly, tumoral murine models for B-CLL could be established with PLL cells but not with B-CLL cells. JVM-3 cells were efficiently transplanted into nude mice through subcutaneous or intravenous routes. Irradiated female mice appeared to be the optimal recipients for tumor growth. Such murine models for human B-CLL may help the development of therapeutic agents.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0145-2126
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
29
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1347-52
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:15896841-Animals,
pubmed-meshheading:15896841-Cell Line, Tumor,
pubmed-meshheading:15896841-Cell Proliferation,
pubmed-meshheading:15896841-Disease Models, Animal,
pubmed-meshheading:15896841-Female,
pubmed-meshheading:15896841-Flow Cytometry,
pubmed-meshheading:15896841-Histological Techniques,
pubmed-meshheading:15896841-Humans,
pubmed-meshheading:15896841-Immunophenotyping,
pubmed-meshheading:15896841-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:15896841-Male,
pubmed-meshheading:15896841-Mice,
pubmed-meshheading:15896841-Mice, Nude,
pubmed-meshheading:15896841-Sex Factors,
pubmed-meshheading:15896841-Survival Rate,
pubmed-meshheading:15896841-Transplantation, Heterologous,
pubmed-meshheading:15896841-Tumor Markers, Biological,
pubmed-meshheading:15896841-Xenograft Model Antitumor Assays
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
Establishment of a novel human B-CLL-like xenograft model in nude mouse.
|
| pubmed:affiliation |
Laboratory of Cellular Therapy and Cancer Immunobiology, Brest University Medical School Hospital, BP824, F29609 Brest Cedex, France. severine.loisel@univ-brest.fr
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|