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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2005-5-17
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pubmed:abstractText |
To determine the effect of the DNA repair gene XPD Arg156Arg polymorphism on the risk of lung cancer in a North-Eastern Chinese population, a hospital-based case-control study was designed consisting of 149 newly diagnosis subjects with lung cancer and 137 cancer-free control subjects matched on age (+/-3 years), gender and ethnicity. In the whole study group, XPD Arg156Arg was not associated with risk of lung cancer. In stratified analyses, the variant A-allele of XPD Arg156Arg was associated with increased risk of adenocarcinoma of lung (AA/AC versus CC; adjusted OR=1.65; 95% CI=1.09-2.50) (P=0.02). Furthermore, the presence of one or two variant A-alleles was associated with increased risk for lung cancer (OR=2.49; 95% CI=1.10-5.64) (P=0.03) and adenocarcinoma of lung (OR=5.60; 95% CI=1.52-20.56) (P=0.005) among never-smokers only. These results suggest a possible gene-environment interaction. This is the first study to report a significant association of XPD Arg156Arg with risk of lung cancer.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0304-3835
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
223
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
219-26
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15896456-Adenocarcinoma,
pubmed-meshheading:15896456-Adult,
pubmed-meshheading:15896456-Aged,
pubmed-meshheading:15896456-Arginine,
pubmed-meshheading:15896456-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:15896456-Case-Control Studies,
pubmed-meshheading:15896456-China,
pubmed-meshheading:15896456-DNA Helicases,
pubmed-meshheading:15896456-DNA Repair,
pubmed-meshheading:15896456-DNA-Binding Proteins,
pubmed-meshheading:15896456-Ethnic Groups,
pubmed-meshheading:15896456-Female,
pubmed-meshheading:15896456-Genetic Predisposition to Disease,
pubmed-meshheading:15896456-Humans,
pubmed-meshheading:15896456-Lung Neoplasms,
pubmed-meshheading:15896456-Male,
pubmed-meshheading:15896456-Middle Aged,
pubmed-meshheading:15896456-Polymorphism, Genetic,
pubmed-meshheading:15896456-Risk Factors,
pubmed-meshheading:15896456-Sex Factors,
pubmed-meshheading:15896456-Smoking,
pubmed-meshheading:15896456-Transcription Factors,
pubmed-meshheading:15896456-Xeroderma Pigmentosum Group D Protein
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pubmed:year |
2005
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pubmed:articleTitle |
The DNA repair gene ERCC2/XPD polymorphism Arg 156Arg (A22541C) and risk of lung cancer in a Chinese population.
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pubmed:affiliation |
Institute of Cell Biology, Zhejiang University, Hangzhou (310031), Zhejiang Province, People's Republic of China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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