Source:http://linkedlifedata.com/resource/pubmed/id/15896199
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2005-5-17
|
| pubmed:abstractText |
Matching of donor and recipient for the class I human leukocyte antigen-C (HLA-C)-encoded natural killer (NK) epitopes has been reported to influence stem-cell (SC) graft outcome, but a consistent picture has not yet emerged. We have analyzed transplant outcome in 104 unrelated SC grafts in relation to NK epitope (C1 and C2) matching and donor killer cell immunoglobulin-like receptor (KIR) genotype. NK epitope mismatching in the rejection direction was strongly associated with an increased probability of rejection subsequent to engraftment. The prevalence of grades III-IV acute graft-vs-host disease (GVHD) was significantly higher and occurred significantly earlier when there was NK epitope mismatching in the GVH direction. Higher transplant-related mortality and lower disease-free survival rates were associated with epitope mismatching regardless of the mismatch direction. A greater number of KIR receptors, both activating and inhibitory, in the donor protected against grades III-IV GVHD and improved survival.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0001-2815
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
65
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
519-28
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:15896199-Adolescent,
pubmed-meshheading:15896199-Adult,
pubmed-meshheading:15896199-Bone Marrow Transplantation,
pubmed-meshheading:15896199-Child,
pubmed-meshheading:15896199-Child, Preschool,
pubmed-meshheading:15896199-Disease-Free Survival,
pubmed-meshheading:15896199-Epitopes,
pubmed-meshheading:15896199-Female,
pubmed-meshheading:15896199-Genes, MHC Class I,
pubmed-meshheading:15896199-Genotype,
pubmed-meshheading:15896199-Graft vs Host Disease,
pubmed-meshheading:15896199-HLA-C Antigens,
pubmed-meshheading:15896199-Histocompatibility Testing,
pubmed-meshheading:15896199-Humans,
pubmed-meshheading:15896199-Infant,
pubmed-meshheading:15896199-Killer Cells, Natural,
pubmed-meshheading:15896199-Male,
pubmed-meshheading:15896199-Middle Aged,
pubmed-meshheading:15896199-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:15896199-Receptors, Immunologic,
pubmed-meshheading:15896199-Receptors, KIR,
pubmed-meshheading:15896199-Recurrence,
pubmed-meshheading:15896199-Stem Cell Transplantation,
pubmed-meshheading:15896199-Time Factors,
pubmed-meshheading:15896199-Transplantation Conditioning,
pubmed-meshheading:15896199-Transplantation Immunology,
pubmed-meshheading:15896199-Treatment Outcome
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
Natural killer cell HLA-C epitopes and killer cell immunoglobulin-like receptors both influence outcome of mismatched unrelated donor bone marrow transplants.
|
| pubmed:affiliation |
Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Perth, Australia.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|