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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-3
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pubmed:dateCreated |
2005-5-27
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pubmed:abstractText |
The effects of tacrolimus on murine acute lung injury were tested, especially in comparison to dexamethasone. Acute lung injury was induced by intratracheal instillation of bleomycin. Oral tacrolimus significantly improved survival rates of bleomycin-exposed mice, while cyclosporin A or dexamethasone did not. After instillation of bleomycin (day 0), a migration of neutrophils into alveolar spaces peaked on day 3, with concomitant increases of chemokines. On day 6, marked morphological changes in the lungs were observed. All these changes were significantly inhibited by tacrolimus. Furthermore, DNA ladder and immunohistochemical analyses of lungs showed that apoptosis of lung cells appeared on day 6 and was abolished only by the treatment of tacrolimus. These results suggest that both anti-inflammatory and anti-apoptotic action of tacrolimus contribute to improvement of bleomycin-induced acute lung injury.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0014-2999
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
515
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
169-78
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15894307-Acute Disease,
pubmed-meshheading:15894307-Animals,
pubmed-meshheading:15894307-Apoptosis,
pubmed-meshheading:15894307-Bleomycin,
pubmed-meshheading:15894307-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:15894307-Chemokines,
pubmed-meshheading:15894307-DNA Fragmentation,
pubmed-meshheading:15894307-Dexamethasone,
pubmed-meshheading:15894307-Dose-Response Relationship, Drug,
pubmed-meshheading:15894307-Female,
pubmed-meshheading:15894307-Immunosuppressive Agents,
pubmed-meshheading:15894307-In Situ Nick-End Labeling,
pubmed-meshheading:15894307-Lung,
pubmed-meshheading:15894307-Lung Diseases,
pubmed-meshheading:15894307-Mice,
pubmed-meshheading:15894307-Mice, Inbred C57BL,
pubmed-meshheading:15894307-Specific Pathogen-Free Organisms,
pubmed-meshheading:15894307-Survival Rate,
pubmed-meshheading:15894307-Tacrolimus
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pubmed:year |
2005
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pubmed:articleTitle |
Tacrolimus (FK506) has protective actions against murine bleomycin-induced acute lung injuries.
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pubmed:affiliation |
Department of Immunology and Inflammation, Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 2-1-6 Kashima, Yodogawa-ku, Osaka 532-8514, Japan. tadatsura_koshika@po.fujisawa.co.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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