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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2005-5-16
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pubmed:abstractText |
We developed a rodent model that mimics the osteoblastic and osteolytic changes associated with human metastatic prostate cancer. Microarray analysis identified MMP-7, cathepsin-K, and apolipoprotein D as being upregulated at the tumor-bone interface. MMP-7, which was produced by osteoclasts at the tumor-bone interface, was capable of processing RANKL to a soluble form that promoted osteoclast activation. MMP-7-deficient mice demonstrated reduced prostate tumor-induced osteolysis and RANKL processing. This study suggests that inhibition of MMP-7 will have therapeutic benefit in the treatment of prostate cancer-induced osteolysis.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acid Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/Actins,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 7,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Osteoprotegerin,
http://linkedlifedata.com/resource/pubmed/chemical/Parathyroid Hormone-Related Protein,
http://linkedlifedata.com/resource/pubmed/chemical/RANK Ligand,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Activator of Nuclear...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/TNFRSF11A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TNFRSF11B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TNFSF11 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfrsf11a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfrsf11b protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfrsf11b protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfsf11 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/tartrate-resistant acid phosphatase
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1535-6108
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pubmed:author |
pubmed-author:AcuffHeath BHB,
pubmed-author:BegtrupJennifer LJL,
pubmed-author:FingletonBarbaraB,
pubmed-author:FutakuchiMitsuruM,
pubmed-author:HikosakaAtsuyaA,
pubmed-author:KawaiNoriyasuN,
pubmed-author:LynchConor CCC,
pubmed-author:MartinMichelle DMD,
pubmed-author:MatrisianLynn MLM,
pubmed-author:PetersonTodd ETE,
pubmed-author:ShiraiTomoyukiT,
pubmed-author:SinghRakesh KRK,
pubmed-author:Vargo-GogolaTracy CTC
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
485-96
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15894268-Acid Phosphatase,
pubmed-meshheading:15894268-Actins,
pubmed-meshheading:15894268-Animals,
pubmed-meshheading:15894268-Carrier Proteins,
pubmed-meshheading:15894268-Disease Models, Animal,
pubmed-meshheading:15894268-Down-Regulation,
pubmed-meshheading:15894268-Gene Expression,
pubmed-meshheading:15894268-Gene Expression Profiling,
pubmed-meshheading:15894268-Glycoproteins,
pubmed-meshheading:15894268-Humans,
pubmed-meshheading:15894268-Isoenzymes,
pubmed-meshheading:15894268-Male,
pubmed-meshheading:15894268-Matrix Metalloproteinase 7,
pubmed-meshheading:15894268-Membrane Glycoproteins,
pubmed-meshheading:15894268-Mice,
pubmed-meshheading:15894268-Mice, Inbred C57BL,
pubmed-meshheading:15894268-Mice, Knockout,
pubmed-meshheading:15894268-Models, Biological,
pubmed-meshheading:15894268-Monocytes,
pubmed-meshheading:15894268-Osteoclasts,
pubmed-meshheading:15894268-Osteolysis,
pubmed-meshheading:15894268-Osteoprotegerin,
pubmed-meshheading:15894268-Parathyroid Hormone-Related Protein,
pubmed-meshheading:15894268-Prostatic Neoplasms,
pubmed-meshheading:15894268-RANK Ligand,
pubmed-meshheading:15894268-Rats,
pubmed-meshheading:15894268-Rats, Inbred F344,
pubmed-meshheading:15894268-Receptor Activator of Nuclear Factor-kappa B,
pubmed-meshheading:15894268-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:15894268-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:15894268-Skull,
pubmed-meshheading:15894268-Up-Regulation
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pubmed:year |
2005
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pubmed:articleTitle |
MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL.
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pubmed:affiliation |
Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee 37232, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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