Linked Life Data

15894104

Source:http://linkedlifedata.com/resource/pubmed/id/15894104

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2005-5-16
pubmed:abstractText
Regulatory T cells (Treg) in broader terms consist of different subsets of T cells that are characterized by their ability to suppress proliferation of conventional effector T cells by various means. To date three main groups of Treg can de distinguished, mainly by their functional properties. The regulatory T cell family: distinct subsets and their interrelations. Briefly, T regulatory (Tr)-1 cells as well as T helper (Th)-3 T cells express common T cell markers such as CD4 and are characterized by secretion of IL-10 and TGF-beta, which provides a means by which proliferation of conventional CD4(+) cells is blocked. In contrast, genuine Treg that are characterized by their expression of CD25 block T cell proliferation by an unknown cell to cell contact dependent mechanism. However, there are many overlapping features shared by the different subtypes of regulatory T cells and the common denominator is the production of regulatory cytokines such as IL-10 and TGF-beta.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0165-2478
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
99
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8-11
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Dendritic cells in tolerance induction.
pubmed:affiliation
Department of Dermatol., Univ. of Heidelberg, Vossstr. 2, D-69115 Heidelberg, Germany. alexander.enk@med.uni-heidelberg.de
pubmed:publicationType
Journal Article, Review