Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2005-7-8
pubmed:abstractText
A cohort study was performed to investigate the risk factors for colonization with high-level aminoglycoside-resistant enterococci (HLARE) in intensive care unit (ICU) patients. Colonization was investigated by performing surveillance samples during ICU stay. Clonal relatedness of the isolates was assessed by pulsed-field gel electrophoresis. Eighty-six patients with an ICU stay of >48 h were included; two were colonized with HLARE at admission, and 24 (28.5%) acquired HLARE during their stay in the ICU. HLARE were initially isolated from rectal swabs alone. Thirty-five percent of Enterococcus faecalis and 57% of E. faecium showed high-level resistance to gentamicin or streptomycin. Most isolates were clonally unrelated. Using multi-variate analysis, the only variable associated with HLARE colonization was previous antimicrobial use. Five patients had HLARE isolated from clinical samples, three of them with infection; in all of these, colonization with the same clone had been detected previously by surveillance samples. We conclude that most infections due to HLARE in the ICU are preceded by previous colonization, and that antimicrobial use is the main risk factor for colonization.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0195-6701
pubmed:author
pubmed:issnType
Print
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
353-9
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:15893852-Aminoglycosides, pubmed-meshheading:15893852-Anti-Bacterial Agents, pubmed-meshheading:15893852-Cohort Studies, pubmed-meshheading:15893852-Cross Infection, pubmed-meshheading:15893852-DNA, Bacterial, pubmed-meshheading:15893852-DNA Fingerprinting, pubmed-meshheading:15893852-Drug Resistance, Bacterial, pubmed-meshheading:15893852-Electrophoresis, Gel, Pulsed-Field, pubmed-meshheading:15893852-Enterococcus, pubmed-meshheading:15893852-Enterococcus faecalis, pubmed-meshheading:15893852-Enterococcus faecium, pubmed-meshheading:15893852-Female, pubmed-meshheading:15893852-Genotype, pubmed-meshheading:15893852-Gentamicins, pubmed-meshheading:15893852-Gram-Positive Bacterial Infections, pubmed-meshheading:15893852-Humans, pubmed-meshheading:15893852-Intensive Care Units, pubmed-meshheading:15893852-Male, pubmed-meshheading:15893852-Molecular Epidemiology, pubmed-meshheading:15893852-Risk Factors, pubmed-meshheading:15893852-Spain, pubmed-meshheading:15893852-Streptomycin
pubmed:year
2005
pubmed:articleTitle
Colonization by high-level aminoglycoside-resistant enterococci in intensive care unit patients: epidemiology and clinical relevance.
pubmed:affiliation
Sección de Enfermedades Infecciosas, Hospital Universitario Virgen Macarena, Avda. Dr. Fedriani, 3, 41071 Sevilla, Spain. jrb@nacom.es
pubmed:publicationType
Journal Article