Linked Life Data

15892296

Source:http://linkedlifedata.com/resource/pubmed/id/15892296

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2005-5-16
pubmed:abstractText
Central nervous system atypical teratoid/rhabdoid tumor (AT/RT) and choroid plexus carcinoma (CPC) are rare, highly malignant tumors that predominantly arise in infants and young children. Overlapping clinical, histologic, ultrastructural, or immunophenotypic features may obscure the diagnosis in some cases. AT/RT is characterized by deletions and/or mutations of the INI1 tumor-suppressor gene on chromosome band 22q11.2. We have recently developed an INI1 immunohistochemical staining assay. Negative staining of tumor cells resulting from inactivation of the INI1 gene is a consistent feature of AT/RT. Mutations of INI1 in some CPCs have been reported. The purpose of the present study was to determine if immunohistochemical staining with an INI1 antibody would provide a sensitive means of distinguishing between CPC and AT/RT. We examined 28 tumors with a submitted diagnosis of CPC. Twenty-one CPCs showed retained expression of INI1 and seven tumors showed loss of INI1 expression. Cytogenetic, FISH, and/or INI1 mutation results were also available for 13 tumors. In three of the seven cases, monosomy 22 was the only cytogenetic abnormality, suggestive of AT/RT. However, monosomy 22 was also identified in 3 tumors with complex karyotypes that retained INI1 expression. The 7 tumors that were immunonegative for INI1 had features that were consistent with AT/RT. Immunostaining for INI1 protein is retained in the majority of CPC and is lost in AT/RT. This expression pattern seems to better define the 2 groups of tumors than does light or electron microscopy, routine immunohistochemistry, or cytogenetic analysis alone.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-3069
pubmed:author
pubmed:issnType
Print
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
391-7
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:15892296-Adolescent, pubmed-meshheading:15892296-Apoptosis, pubmed-meshheading:15892296-Carcinoma, pubmed-meshheading:15892296-Child, pubmed-meshheading:15892296-Child, Preschool, pubmed-meshheading:15892296-Choroid Plexus Neoplasms, pubmed-meshheading:15892296-Chromosomal Proteins, Non-Histone, pubmed-meshheading:15892296-DNA-Binding Proteins, pubmed-meshheading:15892296-Female, pubmed-meshheading:15892296-Gene Expression Regulation, Neoplastic, pubmed-meshheading:15892296-Humans, pubmed-meshheading:15892296-Immunohistochemistry, pubmed-meshheading:15892296-In Situ Hybridization, pubmed-meshheading:15892296-Infant, pubmed-meshheading:15892296-Male, pubmed-meshheading:15892296-Mucin-1, pubmed-meshheading:15892296-Staining and Labeling, pubmed-meshheading:15892296-Teratoma, pubmed-meshheading:15892296-Transcription Factors, pubmed-meshheading:15892296-Tumor Markers, Biological
pubmed:year
2005
pubmed:articleTitle
INI1 protein expression distinguishes atypical teratoid/rhabdoid tumor from choroid plexus carcinoma.
pubmed:affiliation
Department of Pathology, University of Pennsylvania School of Medicine and Children's Hospital of Philadelphia, 3615 Civic Center Blvd., Philadelphia, PA 19104, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural