| pubmed-article:15891929 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15891929 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:15891929 | lifeskim:mentions | umls-concept:C0105770 | lld:lifeskim |
| pubmed-article:15891929 | lifeskim:mentions | umls-concept:C0431129 | lld:lifeskim |
| pubmed-article:15891929 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:15891929 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:15891929 | lifeskim:mentions | umls-concept:C0205214 | lld:lifeskim |
| pubmed-article:15891929 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15891929 | pubmed:dateCreated | 2005-6-28 | lld:pubmed |
| pubmed-article:15891929 | pubmed:abstractText | Dysregulation of the Wnt signalling pathway contributes to developmental abnormalities and carcinogenesis of solid tumours. Here, we examined beta-catenin and adenomatous polyposis coli (APC) by mutational analysis in pituitary adenomas (n=60) and a large series of craniopharyngiomas (n=41). Furthermore, the expression pattern of beta-catenin was immunohistochemically analysed in a cohort of tumours and cysts of the sellar region including pituitary adenomas (n=58), craniopharyngiomas (n=57), arachnoidal cysts (n=8), Rathke's cleft cysts (n=10) and xanthogranulomas (n=6). Whereas APC mutations were not detectable in any tumour entity, beta-catenin mutations were present in 77% of craniopharyngiomas, exclusively of the adamantinomatous subtype. All mutations affected exon 3, which encodes the degradation targeting box of beta-catenin compatible with an accumulation of nuclear beta-catenin protein. In addition, a novel 81-bp deletion of this exonic region was detected in one case. Immunohistochemical analysis confirmed a shift from membrane-bound to nuclear accumulation of beta-catenin in 94% of the adamantinomatous tumours. Aberrant distribution patterns of beta-catenin were never observed in the other tumour entities under study. We conclude that beta-catenin mutations and/or nuclear accumulation serve as diagnostic hallmarks of the adamantinomatous variant, setting it apart from the papillary variant of craniopharyngioma. | lld:pubmed |
| pubmed-article:15891929 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15891929 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15891929 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15891929 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15891929 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15891929 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15891929 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15891929 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15891929 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15891929 | pubmed:issn | 0001-6322 | lld:pubmed |
| pubmed-article:15891929 | pubmed:author | pubmed-author:FahlbuschRudo... | lld:pubmed |
| pubmed-article:15891929 | pubmed:author | pubmed-author:HofmannBerndB | lld:pubmed |
| pubmed-article:15891929 | pubmed:author | pubmed-author:KreutzerJürge... | lld:pubmed |
| pubmed-article:15891929 | pubmed:author | pubmed-author:BusleiRolfR | lld:pubmed |
| pubmed-article:15891929 | pubmed:author | pubmed-author:HahnenEricE | lld:pubmed |
| pubmed-article:15891929 | pubmed:author | pubmed-author:NoldeMichaelM | lld:pubmed |
| pubmed-article:15891929 | pubmed:author | pubmed-author:MeissnerSteph... | lld:pubmed |
| pubmed-article:15891929 | pubmed:author | pubmed-author:EyupogluIlker... | lld:pubmed |
| pubmed-article:15891929 | pubmed:author | pubmed-author:SiebzehnrüblF... | lld:pubmed |
| pubmed-article:15891929 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15891929 | pubmed:volume | 109 | lld:pubmed |
| pubmed-article:15891929 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15891929 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15891929 | pubmed:pagination | 589-97 | lld:pubmed |
| pubmed-article:15891929 | pubmed:dateRevised | 2007-11-9 | lld:pubmed |
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| pubmed-article:15891929 | pubmed:meshHeading | pubmed-meshheading:15891929... | lld:pubmed |
| pubmed-article:15891929 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15891929 | pubmed:articleTitle | Common mutations of beta-catenin in adamantinomatous craniopharyngiomas but not in other tumours originating from the sellar region. | lld:pubmed |
| pubmed-article:15891929 | pubmed:affiliation | Department of Neuropathology, Friedrich-Alexander University Erlangen-Nuremberg, Krankenhausstrasse 8-10, 91054, Erlangen, Germany. rolf.buslei@neuropatho.imed.uni-erlangen.de | lld:pubmed |
| pubmed-article:15891929 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15891929 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15891929 | lld:pubmed |
