Source:http://linkedlifedata.com/resource/pubmed/id/15891929
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2005-6-28
|
| pubmed:abstractText |
Dysregulation of the Wnt signalling pathway contributes to developmental abnormalities and carcinogenesis of solid tumours. Here, we examined beta-catenin and adenomatous polyposis coli (APC) by mutational analysis in pituitary adenomas (n=60) and a large series of craniopharyngiomas (n=41). Furthermore, the expression pattern of beta-catenin was immunohistochemically analysed in a cohort of tumours and cysts of the sellar region including pituitary adenomas (n=58), craniopharyngiomas (n=57), arachnoidal cysts (n=8), Rathke's cleft cysts (n=10) and xanthogranulomas (n=6). Whereas APC mutations were not detectable in any tumour entity, beta-catenin mutations were present in 77% of craniopharyngiomas, exclusively of the adamantinomatous subtype. All mutations affected exon 3, which encodes the degradation targeting box of beta-catenin compatible with an accumulation of nuclear beta-catenin protein. In addition, a novel 81-bp deletion of this exonic region was detected in one case. Immunohistochemical analysis confirmed a shift from membrane-bound to nuclear accumulation of beta-catenin in 94% of the adamantinomatous tumours. Aberrant distribution patterns of beta-catenin were never observed in the other tumour entities under study. We conclude that beta-catenin mutations and/or nuclear accumulation serve as diagnostic hallmarks of the adamantinomatous variant, setting it apart from the papillary variant of craniopharyngioma.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0001-6322
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
109
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
589-97
|
| pubmed:dateRevised |
2007-11-9
|
| pubmed:meshHeading |
pubmed-meshheading:15891929-Adolescent,
pubmed-meshheading:15891929-Adult,
pubmed-meshheading:15891929-Aged,
pubmed-meshheading:15891929-Base Sequence,
pubmed-meshheading:15891929-Child,
pubmed-meshheading:15891929-Child, Preschool,
pubmed-meshheading:15891929-Craniopharyngioma,
pubmed-meshheading:15891929-Cytoskeletal Proteins,
pubmed-meshheading:15891929-DNA Mutational Analysis,
pubmed-meshheading:15891929-Female,
pubmed-meshheading:15891929-Genes, APC,
pubmed-meshheading:15891929-Humans,
pubmed-meshheading:15891929-Immunohistochemistry,
pubmed-meshheading:15891929-Male,
pubmed-meshheading:15891929-Middle Aged,
pubmed-meshheading:15891929-Mutation,
pubmed-meshheading:15891929-Pituitary Neoplasms,
pubmed-meshheading:15891929-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:15891929-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15891929-Sella Turcica,
pubmed-meshheading:15891929-Trans-Activators,
pubmed-meshheading:15891929-beta Catenin
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
Common mutations of beta-catenin in adamantinomatous craniopharyngiomas but not in other tumours originating from the sellar region.
|
| pubmed:affiliation |
Department of Neuropathology, Friedrich-Alexander University Erlangen-Nuremberg, Krankenhausstrasse 8-10, 91054, Erlangen, Germany. rolf.buslei@neuropatho.imed.uni-erlangen.de
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|