Linked Life Data

15891070

Source:http://linkedlifedata.com/resource/pubmed/id/15891070

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2005-5-13
pubmed:abstractText
The gastrointestinal tract (GIT) appears to be the main site of entry for the pathological isoform of prions (PrP(sc)). To understand how the PrP(sc) internalization process occurs, it is important to characterize the cell types that express normal prion protein (PrP(c)) along the GIT. To do so, we studied the distribution of PrP(c) in the rat, monkey, and cow GIT. Using Western blot analysis, we found that PrP(c) is expressed in all digestive regions of the three species. Immunoreactivity for PrP(c) was found throughout the GIT in epithelial cells sharing the neuroendocrine (NE) phenotype. Immunostained cells appeared scattered throughout the epithelium of fundic and pyloric glands as well as in intestinal villi and crypts.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0077-8923
pubmed:author
pubmed:issnType
Print
pubmed:volume
1040
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
391-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Comparative study of PrPc expression in rat, monkey, and cow gastrointestinal tract.
pubmed:affiliation
Department of Histology and Pathology, University of Navarra, School of Medicine, Pamplona, Spain. zmarcos@alumni.unav.es
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't