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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2005-5-18
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pubmed:abstractText |
Urokinase (uPA)-induced signaling in human vascular smooth muscle cells (VSMC) elicits important cellular functional responses, such as cell migration and proliferation. However, how intracellular signaling is linked to glycolipid-anchored uPA receptor (uPAR) is unknown. We provide evidence that uPAR activation by uPA induces its association with platelet-derived growth factor receptor (PDGFR)-beta. The interaction results in PDGF-independent PDGFR-beta activation by phosphorylation of cytoplasmic tyrosine kinase domains and receptor dimerization. Association of the receptors as well as the tyrosine kinase activity of PDGFR-beta are decisive in mediating uPA-induced downstream signaling that regulates VSMC migration and proliferation. These findings provide a molecular basis for mechanisms VSMC use to induce uPAR- and PDGFR-directed signaling. The processes may be relevant to VSMC function and vascular remodeling.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-10207096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-10508235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-10615432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-10712389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-10995743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-11036621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-11359936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-11360187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-11413086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-11818541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-12124174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-12377732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-12461559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-12576295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-12637327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-12719789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-12920039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-1331068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-1378833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-14996938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-15166012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-15234225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-15277195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-1646395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-1715292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-2114227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-2166055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-2175209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-2783498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-7528215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-7615828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-7954456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-8107807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-8703217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-8772189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-8910604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-9295297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-9315743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-9351457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-9417082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-9609090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-9684800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15889147-9690618
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0261-4189
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1787-97
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15889147-Cells, Cultured,
pubmed-meshheading:15889147-DNA-Binding Proteins,
pubmed-meshheading:15889147-Dimerization,
pubmed-meshheading:15889147-Humans,
pubmed-meshheading:15889147-Muscle, Smooth, Vascular,
pubmed-meshheading:15889147-Phosphorylation,
pubmed-meshheading:15889147-Receptor, Platelet-Derived Growth Factor beta,
pubmed-meshheading:15889147-STAT1 Transcription Factor,
pubmed-meshheading:15889147-Trans-Activators,
pubmed-meshheading:15889147-Urokinase-Type Plasminogen Activator,
pubmed-meshheading:15889147-rhoA GTP-Binding Protein
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pubmed:year |
2005
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pubmed:articleTitle |
Urokinase-induced signaling in human vascular smooth muscle cells is mediated by PDGFR-beta.
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pubmed:affiliation |
Nephrology Department, Hannover Medical School, Carl-Neuberg-Strasse 1, D-30625 Hannover, Germany. kiian.ioulia@mh-hannover.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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