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pubmed:abstractText |
O(6)-methylguanine methyltransferase (MGMT) repairs inappropriately methylated guanine in DNA. MGMT mutations have not previously been reported in cancers, but in colorectal tumours MGMT promoter methylation is common and has been associated with increased G:C>A:T transitions, a high frequency of K-ras mutations, and low level microsatellite instability (MSI low). However, some have suggested that MGMT changes are background or secondary events, with little importance for tumorigenesis.
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pubmed:affiliation |
Colorectal Cancer Unit, Cancer Research UK, St Mark's Hospital, Watford Rd, Harrow HA1 3UK, UK.
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