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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2005-5-11
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pubmed:abstractText |
Hepatitis C virus (HCV) infects millions of people worldwide. Therapy is limited, and treatment does not produce a sustained response in the majority of patients. Development of new agents has been hampered by the lack of a convenient animal model. The aim of this study was to determine whether an immunocompetent rat, tolerized and transplanted with a human hepatoma cell line (Huh 7 cells), could be used to sustain an HCV infection.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0016-5085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
128
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1416-23
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15887122-Animals,
pubmed-meshheading:15887122-Cell Line, Tumor,
pubmed-meshheading:15887122-Disease Models, Animal,
pubmed-meshheading:15887122-Female,
pubmed-meshheading:15887122-Hepacivirus,
pubmed-meshheading:15887122-Hepatitis C, Chronic,
pubmed-meshheading:15887122-Hepatoblastoma,
pubmed-meshheading:15887122-Immunocompetence,
pubmed-meshheading:15887122-Liver Neoplasms,
pubmed-meshheading:15887122-Neoplasm Transplantation,
pubmed-meshheading:15887122-Pregnancy,
pubmed-meshheading:15887122-Rats,
pubmed-meshheading:15887122-Rats, Sprague-Dawley,
pubmed-meshheading:15887122-Viral Nonstructural Proteins
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pubmed:year |
2005
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pubmed:articleTitle |
A novel immunocompetent rat model of HCV infection and hepatitis.
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pubmed:affiliation |
Department of Medicine, Division of Gastroenterology-Hepatology, University of Connecticut Health Center, Farmington 06030-1845, USA. wu@nso.uchc.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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