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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2005-5-11
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pubmed:abstractText |
The effects of aging on pancreatic acinar cell proliferation have not been clearly defined. Phosphatidylinositol 3-kinase (PI3K)-mediated phosphorylation of Akt is a critical step for proliferation of various cell types and insulin secretion from pancreatic endocrine cells; however, its role in acinar cell proliferation is not known. The purpose of this study was to (1) delineate the effects of aging on pancreatic regeneration after partial pancreatectomy (Px) and (2) define the involvement of the PI3K/Akt pathway in pancreatic regeneration.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Androstadienes,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids,
http://linkedlifedata.com/resource/pubmed/chemical/PD 98059,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/wortmannin
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0016-5085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
128
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1391-404
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15887120-Aging,
pubmed-meshheading:15887120-Androstadienes,
pubmed-meshheading:15887120-Animals,
pubmed-meshheading:15887120-Cell Division,
pubmed-meshheading:15887120-Cells, Cultured,
pubmed-meshheading:15887120-Enzyme Inhibitors,
pubmed-meshheading:15887120-Flavonoids,
pubmed-meshheading:15887120-Male,
pubmed-meshheading:15887120-Mice,
pubmed-meshheading:15887120-Mice, Inbred C57BL,
pubmed-meshheading:15887120-Pancreas, Exocrine,
pubmed-meshheading:15887120-Pancreatectomy,
pubmed-meshheading:15887120-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:15887120-Phosphorylation,
pubmed-meshheading:15887120-Protein-Serine-Threonine Kinases,
pubmed-meshheading:15887120-Proto-Oncogene Proteins,
pubmed-meshheading:15887120-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:15887120-RNA, Small Interfering,
pubmed-meshheading:15887120-Regeneration
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pubmed:year |
2005
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pubmed:articleTitle |
Aging is associated with decreased pancreatic acinar cell regeneration and phosphatidylinositol 3-kinase/Akt activation.
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pubmed:affiliation |
Department of Surgery, The University of Texas Medical Branch, Galveston 77555-0536, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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