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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2005-8-31
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pubmed:abstractText |
The presence of isolated tumor cells in the bone marrow (ITC-BM) is an independent prognostic factor in all stages of breast cancer. Both the expression/amplification of human epithelial growth factor receptor 2 (HER2) and Topoisomerase IIalpha (TOP IIa), a key enzyme of DNA replication and main target of anthracyclins, in breast cancer tissue seem to have predictive value regarding the effectiveness of systemic therapies.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anthracyclines,
http://linkedlifedata.com/resource/pubmed/chemical/Antibiotics, Antineoplastic,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Topoisomerases, Type II,
http://linkedlifedata.com/resource/pubmed/chemical/DNA topoisomerase II alpha,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, erbB-2,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0171-5216
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
131
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
539-46
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15887027-Anthracyclines,
pubmed-meshheading:15887027-Antibiotics, Antineoplastic,
pubmed-meshheading:15887027-Antigens, Neoplasm,
pubmed-meshheading:15887027-Bone Marrow,
pubmed-meshheading:15887027-Bone Marrow Neoplasms,
pubmed-meshheading:15887027-Breast Neoplasms,
pubmed-meshheading:15887027-DNA Topoisomerases, Type II,
pubmed-meshheading:15887027-DNA-Binding Proteins,
pubmed-meshheading:15887027-Female,
pubmed-meshheading:15887027-Humans,
pubmed-meshheading:15887027-Immunohistochemistry,
pubmed-meshheading:15887027-In Situ Hybridization, Fluorescence,
pubmed-meshheading:15887027-Predictive Value of Tests,
pubmed-meshheading:15887027-Prognosis,
pubmed-meshheading:15887027-Receptor, erbB-2,
pubmed-meshheading:15887027-Risk Factors,
pubmed-meshheading:15887027-Tumor Markers, Biological
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pubmed:year |
2005
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pubmed:articleTitle |
Isolated tumor cells in the bone marrow (ITC-BM) of breast cancer patients before and after anthracyclin based therapy: influenced by the HER2- and Topoisomerase IIalpha-status of the primary tumor?
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pubmed:affiliation |
I. Frauenklinik, Klinikum der Ludwig-Maximilians-Universität, Maistrasse 11, 80337 Munich, Germany. Christian.Schindlbeck@med.uni-muenchen.de
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pubmed:publicationType |
Journal Article
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