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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2005-8-9
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pubmed:abstractText |
An excess of the soluble receptor, fms-like tyrosine kinase 1 (sFlt-1) may contribute to maternal vascular dysfunction in women with preeclampsia by binding and thereby reducing concentrations of free vascular endothelial growth factor and placental growth factor (PlGF) in the circulation. The putative stimulus for increased sFlt-1 during preeclampsia, placental hypoxia due to poor perfusion, is common to both preeclampsia and idiopathic intrauterine growth restriction. However, the latter condition occurs without maternal vascular disease.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0021-972X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4895-903
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pubmed:dateRevised |
2009-11-25
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pubmed:meshHeading |
pubmed-meshheading:15886253-Adult,
pubmed-meshheading:15886253-Blood Pressure,
pubmed-meshheading:15886253-Blotting, Western,
pubmed-meshheading:15886253-Case-Control Studies,
pubmed-meshheading:15886253-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:15886253-Female,
pubmed-meshheading:15886253-Humans,
pubmed-meshheading:15886253-Infant, Newborn,
pubmed-meshheading:15886253-Infant, Small for Gestational Age,
pubmed-meshheading:15886253-Placenta,
pubmed-meshheading:15886253-Pre-Eclampsia,
pubmed-meshheading:15886253-Pregnancy,
pubmed-meshheading:15886253-Pregnancy Proteins,
pubmed-meshheading:15886253-Proteins,
pubmed-meshheading:15886253-RNA, Messenger,
pubmed-meshheading:15886253-Solubility
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pubmed:year |
2005
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pubmed:articleTitle |
Soluble fms-like tyrosine kinase 1 is increased in preeclampsia but not in normotensive pregnancies with small-for-gestational-age neonates: relationship to circulating placental growth factor.
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pubmed:affiliation |
Magee-Womens Research Institute, University of Pittsburgh, 204 Craft Avenue, Pittsburgh, Pennsylvania 15213, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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