Linked Life Data

15886117

Source:http://linkedlifedata.com/resource/pubmed/id/15886117

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-5-11
pubmed:abstractText
In vitro work has defined the TNF receptor family member CD27 as a T and B cell co-stimulatory molecule. Its activity is governed by the transient availability of its TNF-like ligand CD70 on lymphocytes and dendritic cells. Recent studies, enforcing or abrogating CD27 function by genetic or protein intervention in mouse models have revealed key contributions of the CD27-CD70 system to effector and memory T cell formation, which is probably based on improved cell survival. The stimulatory effects of CD27 on B cell function appear to oppose those of CD70, which also has a signaling role. Targeting CD27-CD70 for therapy is attractive but should take into account the fact that constitutive CD27 stimulation culminates in lethal immunodeficiency.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0952-7915
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
275-81
pubmed:dateRevised
2008-5-14
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
CD27 and CD70 in T cell and B cell activation.
pubmed:affiliation
Division of Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands. j.borst@nki.nl
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't