|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1992-6-22
|
|
pubmed:abstractText |
Perfluorodecanoic (PFDA) and perfluorooctanoic (PFOA) acids belong to the structurally diverse group of compounds known to cause peroxisomal proliferation. It has been hypothesized that the common mode of action of these compounds is that they act through an activated coenzyme A (CoA) thioester. Using rat liver microsomal and isolated rat hepatocyte incubation conditions that were effective in producing a CoA conjugate of clofibric acid, no corresponding CoA derivative could be found for either PFDA or PFOA.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0887-2082
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
7
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
25-9
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:1588571-Acyl Coenzyme A,
pubmed-meshheading:1588571-Animals,
pubmed-meshheading:1588571-Chromatography, High Pressure Liquid,
pubmed-meshheading:1588571-Clofibric Acid,
pubmed-meshheading:1588571-Coenzyme A,
pubmed-meshheading:1588571-Decanoic Acids,
pubmed-meshheading:1588571-Female,
pubmed-meshheading:1588571-Fluorocarbons,
pubmed-meshheading:1588571-Liver,
pubmed-meshheading:1588571-Male,
pubmed-meshheading:1588571-Microsomes, Liver,
pubmed-meshheading:1588571-Octanoic Acids,
pubmed-meshheading:1588571-Rats,
pubmed-meshheading:1588571-Rats, Inbred Strains
|
|
pubmed:year |
1992
|
|
pubmed:articleTitle |
Lack of evidence for perfluorodecanoyl- or perfluorooctanoyl-coenzyme A formation in male and female rats.
|
|
pubmed:affiliation |
School of Pharmacy, University of Wisconsin, Madison 53706.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
