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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2005-5-11
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY572193,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY572194,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY572195,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/BK005177,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/BK005178,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/BK005179,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/BK005180,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/BK005181,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/BK005182,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/BK005183,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/BK005487,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/BK005488,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/BK005491
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pubmed:abstractText |
We present seven new vertebrate homologs of the prolactin-releasing hormone receptor (PRLHR) and show that these are found as two separate subtypes, PRLHR1 and PRLHR2. Analysis of a number of vertebrate sequences using phylogeny, pharmacology, and paralogon analysis indicates that the PRLHRs are likely to share a common ancestry with the neuropeptide Y (NPY) receptors. Moreover, a micromolar level of NPY was able to bind and inhibit completely the PRLH-evoked response in PRLHR1-expressing cells. We suggest that an ancestral PRLH peptide started coevolving with a redundant NPY binding receptor, which then became PRLHR, approximately 500 million years ago. The PRLHR1 subtype was shown to have a relatively high evolutionary rate compared to receptors with fixed peptide preference, which could indicate a drastic change in binding preference, thus supporting this hypothesis. This report suggests how gene duplication events can lead to novel peptide ligand/receptor interactions and hence spur the evolution of new physiological functions.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0888-7543
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pubmed:author |
pubmed-author:AnderssonJanJ,
pubmed-author:BjarnadóttirThóra KTK,
pubmed-author:ChowdharyBhanu PBP,
pubmed-author:FredrikssonRobertR,
pubmed-author:FridmanisDavidsD,
pubmed-author:HolmquistTomasT,
pubmed-author:KlovinsJanisJ,
pubmed-author:KukkonenJyrki PJP,
pubmed-author:LagerströmMalin CMC,
pubmed-author:LundinLars-GustavLG,
pubmed-author:PostlethwaitJohn HJH,
pubmed-author:RaudseppTerjeT,
pubmed-author:SchiöthHelgi BHB,
pubmed-author:YanYi-LinYL,
pubmed-author:ZoorobRimaR
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pubmed:issnType |
Print
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
688-703
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15885496-Animals,
pubmed-meshheading:15885496-Base Sequence,
pubmed-meshheading:15885496-Evolution, Molecular,
pubmed-meshheading:15885496-Gene Duplication,
pubmed-meshheading:15885496-Humans,
pubmed-meshheading:15885496-Molecular Sequence Data,
pubmed-meshheading:15885496-Phylogeny,
pubmed-meshheading:15885496-Receptors, G-Protein-Coupled,
pubmed-meshheading:15885496-Receptors, Neuropeptide Y,
pubmed-meshheading:15885496-Vertebrates
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pubmed:year |
2005
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pubmed:articleTitle |
Origin of the prolactin-releasing hormone (PRLH) receptors: evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution.
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pubmed:affiliation |
Department of Neuroscience, Uppsala University, BMC, Box 593, 751 24 Uppsala, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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