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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2005-5-11
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pubmed:abstractText |
Hereditary hemochromatosis (HHC) is a disorder of iron metabolism with variable penetrance. Oxidative stress plays a central role in the progression to cirrhosis. Several enzymes involved in the production or degradation of reactive oxidants, like myeloperoxidase (MPO) and heme oxygenase (HO)-1 are influenced by promotor polymorphisms. This study assessed the impact of polymorphisms of the MPO (-463G/A) and the HO-1 promotors of Vienna (GT)n on the evolution of cirrhosis in patients with HHC.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0168-8278
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
914-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15885363-Adult,
pubmed-meshheading:15885363-Aged,
pubmed-meshheading:15885363-Female,
pubmed-meshheading:15885363-Gene Frequency,
pubmed-meshheading:15885363-Genetic Predisposition to Disease,
pubmed-meshheading:15885363-Genotype,
pubmed-meshheading:15885363-Heme Oxygenase (Decyclizing),
pubmed-meshheading:15885363-Heme Oxygenase-1,
pubmed-meshheading:15885363-Hemochromatosis,
pubmed-meshheading:15885363-Homozygote,
pubmed-meshheading:15885363-Humans,
pubmed-meshheading:15885363-Incidence,
pubmed-meshheading:15885363-Liver Cirrhosis,
pubmed-meshheading:15885363-Male,
pubmed-meshheading:15885363-Membrane Proteins,
pubmed-meshheading:15885363-Middle Aged,
pubmed-meshheading:15885363-Oxidative Stress,
pubmed-meshheading:15885363-Peroxidase,
pubmed-meshheading:15885363-Polymorphism, Genetic,
pubmed-meshheading:15885363-Promoter Regions, Genetic
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pubmed:year |
2005
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pubmed:articleTitle |
Association of myeloperoxidase promotor polymorphism with cirrhosis in patients with hereditary hemochromatosis.
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pubmed:affiliation |
Department of Internal Medicine IV, Gastroenterology and Hepatology, Medical University of Vienna, Währinger Gürtel 18-20, A-1090 Wien, Austria.
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pubmed:publicationType |
Journal Article
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